FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014071036> ?p ?o ?g. }

• W2014071036 endingPage "11" @default.
• W2014071036 startingPage "1" @default.
• W2014071036 abstract "The prognosis of lung cancer is very much limited by the difficulties of diagnosing early stage disease amenable to surgery. Thus, novel diagnostic and therapeutic approaches are urgently needed for this common type of cancer. Recently, epigenetic alterations of tumor cells have been defined for a multitude of tissues and genes. Thus, promoter hypermethylation of tumor suppressor genes, and other targets of neoplasia-associated methylation disturbances, have become the most frequent recurrent alteration in solid tumors and hematologic neoplasia. In lung cancer, several sets of genes including the tumor suppressor gene p16, the DNA repair gene O6-methylguanine-DNA methyltransferase (MGMT), E-cadherin and retinoic acid receptor beta have been shown to be frequently methylated and inactivated. Distinct methylation patterns can provide molecular distinctions between different histologic subtypes of lung cancer. Gene hypermethylation in lung cancer is an early event associated with exposure to tobacco-specific carcinogens. Highly sensitive detection of hypermethylated DNA in sputum and peripheral blood offers a powerful tool for detecting lung cancer at an early stage. Epigenetic alterations in cancer, as opposed to genetic lesions, are potentially reversible. Thus, hypermethylation has been studied as a therapeutic target for agents which revert this epigenotype. The most advanced drugs to inhibit methylation are two azanucleosides, decitabine and its ribonucleoside analogue 5-azacytidine. In vitro, demethylating agents given at low doses reactivate tumor suppressor genes, and in mouse models, the development of lung cancer can be retarded. This effect is more powerful when histone acetylation, as a second epigenetic silencing mechanism, is also inhibited pharmacologically (HDAC inhibitors). Clinical trials of both groups of agents have been performed, and novel demethylating agents which are not incorporated into DNA offer further perspectives for epigenetic therapy of lung cancer and other malignancies." @default.
• W2014071036 created "2016-06-24" @default.
• W2014071036 creator A5004862578 @default.
• W2014071036 creator A5047951694 @default.
• W2014071036 date "2005-07-01" @default.
• W2014071036 modified "2023-10-17" @default.
• W2014071036 title "DNA methylation disturbances as novel therapeutic target in lung cancer: Preclinical and clinical results" @default.
• W2014071036 cites W1484293540 @default.
• W2014071036 cites W1486257535 @default.
• W2014071036 cites W1504197144 @default.
• W2014071036 cites W1504303645 @default.
• W2014071036 cites W1508415075 @default.
• W2014071036 cites W1528634627 @default.
• W2014071036 cites W152974073 @default.
• W2014071036 cites W1530652941 @default.
• W2014071036 cites W1550064533 @default.
• W2014071036 cites W1635667563 @default.
• W2014071036 cites W1810581042 @default.
• W2014071036 cites W1879966002 @default.
• W2014071036 cites W1965527358 @default.
• W2014071036 cites W1967064280 @default.
• W2014071036 cites W1969777426 @default.
• W2014071036 cites W1977706798 @default.
• W2014071036 cites W1977794292 @default.
• W2014071036 cites W1978620346 @default.
• W2014071036 cites W1981745443 @default.
• W2014071036 cites W1983645982 @default.
• W2014071036 cites W1992266159 @default.
• W2014071036 cites W1994465394 @default.
• W2014071036 cites W1995382565 @default.
• W2014071036 cites W1996339349 @default.
• W2014071036 cites W2003363961 @default.
• W2014071036 cites W2007042448 @default.
• W2014071036 cites W2014527208 @default.
• W2014071036 cites W2026666255 @default.
• W2014071036 cites W2031129569 @default.
• W2014071036 cites W2035480447 @default.
• W2014071036 cites W2036734716 @default.
• W2014071036 cites W2037350927 @default.
• W2014071036 cites W2040257851 @default.
• W2014071036 cites W2040347441 @default.
• W2014071036 cites W2044894134 @default.
• W2014071036 cites W2048005397 @default.
• W2014071036 cites W2049413309 @default.
• W2014071036 cites W2050296716 @default.
• W2014071036 cites W2051311335 @default.
• W2014071036 cites W2054249165 @default.
• W2014071036 cites W2057355492 @default.
• W2014071036 cites W2058431178 @default.
• W2014071036 cites W2060300649 @default.
• W2014071036 cites W2073788205 @default.
• W2014071036 cites W2075380047 @default.
• W2014071036 cites W2076808589 @default.
• W2014071036 cites W2081091627 @default.
• W2014071036 cites W2081428426 @default.
• W2014071036 cites W2085288856 @default.
• W2014071036 cites W2091658754 @default.
• W2014071036 cites W2091781237 @default.
• W2014071036 cites W2093156531 @default.
• W2014071036 cites W2093198223 @default.
• W2014071036 cites W2093446050 @default.
• W2014071036 cites W2093587470 @default.
• W2014071036 cites W2094473066 @default.
• W2014071036 cites W2095429655 @default.
• W2014071036 cites W2095728717 @default.
• W2014071036 cites W2096287539 @default.
• W2014071036 cites W2106680700 @default.
• W2014071036 cites W2109895173 @default.
• W2014071036 cites W2110511887 @default.
• W2014071036 cites W2111049773 @default.
• W2014071036 cites W2113459016 @default.
• W2014071036 cites W2115371904 @default.
• W2014071036 cites W2117966565 @default.
• W2014071036 cites W2120649999 @default.
• W2014071036 cites W2120723709 @default.
• W2014071036 cites W2121417064 @default.
• W2014071036 cites W2143617373 @default.
• W2014071036 cites W2145548425 @default.
• W2014071036 cites W2153354021 @default.
• W2014071036 cites W2156134411 @default.
• W2014071036 cites W2160234594 @default.
• W2014071036 cites W2161005330 @default.
• W2014071036 cites W2161252269 @default.
• W2014071036 cites W2165056748 @default.
• W2014071036 cites W2249312162 @default.
• W2014071036 cites W2315916150 @default.
• W2014071036 cites W2333516377 @default.
• W2014071036 cites W253251876 @default.
• W2014071036 cites W378395385 @default.
• W2014071036 doi "https://doi.org/10.1016/j.critrevonc.2005.02.002" @default.
• W2014071036 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15886007" @default.
• W2014071036 hasPublicationYear "2005" @default.
• W2014071036 type Work @default.
• W2014071036 sameAs 2014071036 @default.
• W2014071036 citedByCount "67" @default.
• W2014071036 countsByYear W20140710362012 @default.
• W2014071036 countsByYear W20140710362013 @default.
• W2014071036 countsByYear W20140710362014 @default.

• next