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- W2014073984 abstract "Abstract 6-hydroxydopamine has been shown to deplete brain norepinephrine levels in rats. In the present study, rats were injected intraventricularly with either 6-hydroxydopamine (250 μg per day for 2 days) or a control solution. Seven days later the animals were killed and slices from the hypothalamus, brain stem, cerebrum and cerebellum were incubated in vitro in the presence of norepinephrine. After 6-min exposure to norepinephrine (10 −5 M) there were enhanced cyclic AMP levels in the hypothalamus, cerebrum and brain stem of animals treated with 6-hydroxydopamine when compared to controls. These results suggest that adrenergic denervation supersensitivity to catecholamines may be mediated by adenyl cyclase." @default.
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- W2014073984 date "1972-01-01" @default.
- W2014073984 modified "2023-09-27" @default.
- W2014073984 title "Increased cyclic AMP response to norepinephrine in the rat brain following 6-hydroxydopamine" @default.
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- W2014073984 doi "https://doi.org/10.1016/0028-3908(72)90066-4" @default.
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