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- W2014081567 abstract "Tabled 1 D/V Ent/ Nb cy Neutropenia Mucositis FN PNS Fluid retent mg/m2 Ev Pts G4 Pts (cy) G4 m. dur. (range) G1 G2 G3 G1 Nb m.cum dose md/m2 60/20 3/3 (18) 2 (15) 8(4–2) 2/3 1/3 0 0 3/3 1/3 360 75/20 5/4 (22) 4 (21) 8(2–8) 1/4 2/4 0 0 2/2 0/4 450 75/22.5 4/4 (17) 4 (16) 7(4–8) 1/4 1/4 2/4 3/4 2/2 2/4 210 85/20 4/3 (7) 3 (7) 5(4–7) 1/3 2/3 0 1/3 NA 0/3 170 Open table in a new tab At the 3rd dose level, 2 pts developed DLT (febrile intropenia) concomitant with grade 2–3 mucositis. Less toxicity (hemato and non hemato) was observed within the 4th dose level with reduced dose of V. Activity: 6 pts with meas disease: 3 PR/3 NC, 6 pts with eval disease: 3 IMP/3 NC. Conclusion the last step currently explored consists of D: 100 mg/m2 and V 20 mg/m2. This preliminary analysis suggests promising activity. Preliminary data indicate that the premedication used reduces the incidence and severity of FR. No symptomatic PNS was observed. Pharmacokinetic data will be reported. At the 3rd dose level, 2 pts developed DLT (febrile intropenia) concomitant with grade 2–3 mucositis. Less toxicity (hemato and non hemato) was observed within the 4th dose level with reduced dose of V. Activity: 6 pts with meas disease: 3 PR/3 NC, 6 pts with eval disease: 3 IMP/3 NC. the last step currently explored consists of D: 100 mg/m2 and V 20 mg/m2. This preliminary analysis suggests promising activity. Preliminary data indicate that the premedication used reduces the incidence and severity of FR. No symptomatic PNS was observed. Pharmacokinetic data will be reported." @default.
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- W2014081567 date "1995-11-01" @default.
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- W2014081567 title "938 Docetaxel (D) in combination with vinorelbine (V) as first line CT in PTS with MBC: Phase I dose finding study" @default.
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