FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014089670> ?p ?o ?g. }

• W2014089670 endingPage "1451" @default.
• W2014089670 startingPage "1438" @default.
• W2014089670 abstract "Runx2 is an essential transcription factor for osteoblast development from mesenchymal progenitors. Runx2 regulates gene expression by interacting with numerous transcription factors and co-activators to integrate signaling events within the nucleus. In this study we used affinity purification and proteomic techniques to identify novel Runx2 interacting proteins. One of these proteins is the DEAD box RNA helicase, p68 (Ddx5). p68 regulates many aspects of RNA expression, including transcription and splicing. p68 co-localized with Runx2 in punctate foci within the nucleus. In transcription assays, p68 functioned as a co-activator of Runx2, but its helicase activity was not essential for co-activation. In accordance, Runx2 transcriptional activity was muted in p68-suppressed cells. Surprisingly, osteoblast differentiation of the multipotent progenitor C2C12 cell line was accelerated by p68 suppression and Runx2 suppressed p68 expression in calvarial progenitor cells. Together these data demonstrate that p68 is a novel co-activator for Runx2, but it inhibits osteogenic differentiation of progenitor cells. Moreover Runx2 has an active role in regulating p68 levels in osteoblast precursors. Thus, crosstalk between Runx2 and p68 controls osteoblast specification and maturation at multiple levels. J. Cell. Biochem. 103: 1438–1451, 2008. © 2007 Wiley-Liss, Inc." @default.
• W2014089670 created "2016-06-24" @default.
• W2014089670 creator A5008704314 @default.
• W2014089670 creator A5008755139 @default.
• W2014089670 creator A5029187007 @default.
• W2014089670 creator A5051462785 @default.
• W2014089670 creator A5059051167 @default.
• W2014089670 creator A5069959515 @default.
• W2014089670 creator A5073106686 @default.
• W2014089670 creator A5081119848 @default.
• W2014089670 creator A5082685764 @default.
• W2014089670 creator A5087617560 @default.
• W2014089670 date "2008-01-01" @default.
• W2014089670 modified "2023-10-18" @default.
• W2014089670 title "p68 (Ddx5) interacts with Runx2 and regulates osteoblast differentiation" @default.
• W2014089670 cites W1526634362 @default.
• W2014089670 cites W1935346479 @default.
• W2014089670 cites W1945687446 @default.
• W2014089670 cites W1965760309 @default.
• W2014089670 cites W1976154823 @default.
• W2014089670 cites W1983213855 @default.
• W2014089670 cites W1992941884 @default.
• W2014089670 cites W1996445626 @default.
• W2014089670 cites W1997812904 @default.
• W2014089670 cites W2000702411 @default.
• W2014089670 cites W2014816455 @default.
• W2014089670 cites W2025046506 @default.
• W2014089670 cites W2030782101 @default.
• W2014089670 cites W2034023141 @default.
• W2014089670 cites W2036590917 @default.
• W2014089670 cites W2038208040 @default.
• W2014089670 cites W2038375582 @default.
• W2014089670 cites W2048760401 @default.
• W2014089670 cites W2052052041 @default.
• W2014089670 cites W2053734323 @default.
• W2014089670 cites W2054519108 @default.
• W2014089670 cites W2074354557 @default.
• W2014089670 cites W2075418491 @default.
• W2014089670 cites W2076223951 @default.
• W2014089670 cites W2080028389 @default.
• W2014089670 cites W2085194817 @default.
• W2014089670 cites W2088553641 @default.
• W2014089670 cites W2097785208 @default.
• W2014089670 cites W2110810005 @default.
• W2014089670 cites W2112076644 @default.
• W2014089670 cites W2119542428 @default.
• W2014089670 cites W2119824866 @default.
• W2014089670 cites W2127996002 @default.
• W2014089670 cites W2133761023 @default.
• W2014089670 cites W2148032010 @default.
• W2014089670 cites W2156602474 @default.
• W2014089670 cites W2169522866 @default.
• W2014089670 cites W2171561617 @default.
• W2014089670 cites W2314144775 @default.
• W2014089670 doi "https://doi.org/10.1002/jcb.21526" @default.
• W2014089670 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17960593" @default.
• W2014089670 hasPublicationYear "2008" @default.
• W2014089670 type Work @default.
• W2014089670 sameAs 2014089670 @default.
• W2014089670 citedByCount "62" @default.
• W2014089670 countsByYear W20140896702012 @default.
• W2014089670 countsByYear W20140896702013 @default.
• W2014089670 countsByYear W20140896702014 @default.
• W2014089670 countsByYear W20140896702015 @default.
• W2014089670 countsByYear W20140896702016 @default.
• W2014089670 countsByYear W20140896702017 @default.
• W2014089670 countsByYear W20140896702018 @default.
• W2014089670 countsByYear W20140896702019 @default.
• W2014089670 countsByYear W20140896702020 @default.
• W2014089670 countsByYear W20140896702021 @default.
• W2014089670 countsByYear W20140896702022 @default.
• W2014089670 countsByYear W20140896702023 @default.
• W2014089670 crossrefType "journal-article" @default.
• W2014089670 hasAuthorship W2014089670A5008704314 @default.
• W2014089670 hasAuthorship W2014089670A5008755139 @default.
• W2014089670 hasAuthorship W2014089670A5029187007 @default.
• W2014089670 hasAuthorship W2014089670A5051462785 @default.
• W2014089670 hasAuthorship W2014089670A5059051167 @default.
• W2014089670 hasAuthorship W2014089670A5069959515 @default.
• W2014089670 hasAuthorship W2014089670A5073106686 @default.
• W2014089670 hasAuthorship W2014089670A5081119848 @default.
• W2014089670 hasAuthorship W2014089670A5082685764 @default.
• W2014089670 hasAuthorship W2014089670A5087617560 @default.
• W2014089670 hasConcept C104317684 @default.
• W2014089670 hasConcept C148738053 @default.
• W2014089670 hasConcept C153911025 @default.
• W2014089670 hasConcept C161223559 @default.
• W2014089670 hasConcept C185592680 @default.
• W2014089670 hasConcept C201750760 @default.
• W2014089670 hasConcept C202751555 @default.
• W2014089670 hasConcept C2776363554 @default.
• W2014089670 hasConcept C2778260815 @default.
• W2014089670 hasConcept C28328180 @default.
• W2014089670 hasConcept C54355233 @default.
• W2014089670 hasConcept C67705224 @default.
• W2014089670 hasConcept C68592252 @default.
• W2014089670 hasConcept C86339819 @default.
• W2014089670 hasConcept C86803240 @default.

• next