FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014090135> ?p ?o ?g. }

• W2014090135 endingPage "411" @default.
• W2014090135 startingPage "403" @default.
• W2014090135 abstract "Lung cancer is the leading cause of cancer death worldwide. A diet rich in fruit and vegetables has been shown to reduce the lung cancer risk. However, clinical trials with beta-carotene and retinoids have disappointed, resulted in increased mortality from lung cancer and cardiovascular disease.We have investigated the effects of the two major retinol metabolites, 9-cis-retinoic acid (9-Cis-RA), and 13-cis-retinoic acid (13-Cis-RA), on cell proliferation (MTT assays), intracellular cAMP (cAMP immunoassays), PKA activation (non-radioactive PKA activation assays), and ERK1/2 phosphorylation (Western blots) in immortalized human small airway epithelial cells, HPL1D, a human lung adenocarcinoma cell line, NCI-H322, immortalized human bronchial epithelial cells, BEAS-2B, and in the human small cell lung carcinoma cell line, NCI-H69.Both retinoids increased intracellular cAMP and PKA activation in all cell lines. In BEAS-2B and NCI-H69 cells, the stimulation of cAMP/PKA reduced the phosphorylation of ERK1/2 and inhibited cell proliferation whereas phosphorylation of ERK1/2 and cell proliferation were increased in HPL1D and NCI-H322 cells.Our data have identified a novel mechanism of action of 9-Cis-RA and 13-Cis-RA: activation of PKA in response to increased cAMP. The observed stimulation of cAMP/PKA may inhibit the development of small cell lung carcinoma and other tumors derived from large airway epithelia whereas it may selectively promote the development of lung tumors derived from small airway epithelial cells, such as adenocarcinoma." @default.
• W2014090135 created "2016-06-24" @default.
• W2014090135 creator A5002587767 @default.
• W2014090135 creator A5069875961 @default.
• W2014090135 date "2006-01-01" @default.
• W2014090135 modified "2023-09-23" @default.
• W2014090135 title "Cyclic adenosine monophosphate-dependent cell type-specific modulation of mitogenic signaling by retinoids in normal and neoplastic lung cells" @default.
• W2014090135 cites W121281903 @default.
• W2014090135 cites W1224318197 @default.
• W2014090135 cites W1525444530 @default.
• W2014090135 cites W1557848513 @default.
• W2014090135 cites W1580384359 @default.
• W2014090135 cites W1879435060 @default.
• W2014090135 cites W1969271268 @default.
• W2014090135 cites W1970878584 @default.
• W2014090135 cites W1972547379 @default.
• W2014090135 cites W1980989148 @default.
• W2014090135 cites W1981917112 @default.
• W2014090135 cites W1988078905 @default.
• W2014090135 cites W1989823894 @default.
• W2014090135 cites W1996480893 @default.
• W2014090135 cites W2005822341 @default.
• W2014090135 cites W2046871017 @default.
• W2014090135 cites W2071377067 @default.
• W2014090135 cites W2074571303 @default.
• W2014090135 cites W2085704822 @default.
• W2014090135 cites W2087757403 @default.
• W2014090135 cites W2109848442 @default.
• W2014090135 cites W2121193623 @default.
• W2014090135 cites W2125457087 @default.
• W2014090135 cites W2138047541 @default.
• W2014090135 cites W2162669024 @default.
• W2014090135 cites W2164310509 @default.
• W2014090135 cites W2301077821 @default.
• W2014090135 cites W2317242858 @default.
• W2014090135 cites W2460697663 @default.
• W2014090135 cites W93405764 @default.
• W2014090135 doi "https://doi.org/10.1016/j.cdp.2006.07.008" @default.
• W2014090135 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1761122" @default.
• W2014090135 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17067750" @default.
• W2014090135 hasPublicationYear "2006" @default.
• W2014090135 type Work @default.
• W2014090135 sameAs 2014090135 @default.
• W2014090135 citedByCount "22" @default.
• W2014090135 countsByYear W20140901352012 @default.
• W2014090135 countsByYear W20140901352013 @default.
• W2014090135 countsByYear W20140901352014 @default.
• W2014090135 countsByYear W20140901352016 @default.
• W2014090135 countsByYear W20140901352018 @default.
• W2014090135 countsByYear W20140901352020 @default.
• W2014090135 countsByYear W20140901352023 @default.
• W2014090135 crossrefType "journal-article" @default.
• W2014090135 hasAuthorship W2014090135A5002587767 @default.
• W2014090135 hasAuthorship W2014090135A5069875961 @default.
• W2014090135 hasBestOaLocation W20140901352 @default.
• W2014090135 hasConcept C126322002 @default.
• W2014090135 hasConcept C134018914 @default.
• W2014090135 hasConcept C1491633281 @default.
• W2014090135 hasConcept C170493617 @default.
• W2014090135 hasConcept C2776668983 @default.
• W2014090135 hasConcept C2781121885 @default.
• W2014090135 hasConcept C502942594 @default.
• W2014090135 hasConcept C54355233 @default.
• W2014090135 hasConcept C55493867 @default.
• W2014090135 hasConcept C62112901 @default.
• W2014090135 hasConcept C71924100 @default.
• W2014090135 hasConcept C79879829 @default.
• W2014090135 hasConcept C81885089 @default.
• W2014090135 hasConcept C86803240 @default.
• W2014090135 hasConcept C95444343 @default.
• W2014090135 hasConceptScore W2014090135C126322002 @default.
• W2014090135 hasConceptScore W2014090135C134018914 @default.
• W2014090135 hasConceptScore W2014090135C1491633281 @default.
• W2014090135 hasConceptScore W2014090135C170493617 @default.
• W2014090135 hasConceptScore W2014090135C2776668983 @default.
• W2014090135 hasConceptScore W2014090135C2781121885 @default.
• W2014090135 hasConceptScore W2014090135C502942594 @default.
• W2014090135 hasConceptScore W2014090135C54355233 @default.
• W2014090135 hasConceptScore W2014090135C55493867 @default.
• W2014090135 hasConceptScore W2014090135C62112901 @default.
• W2014090135 hasConceptScore W2014090135C71924100 @default.
• W2014090135 hasConceptScore W2014090135C79879829 @default.
• W2014090135 hasConceptScore W2014090135C81885089 @default.
• W2014090135 hasConceptScore W2014090135C86803240 @default.
• W2014090135 hasConceptScore W2014090135C95444343 @default.
• W2014090135 hasIssue "5" @default.
• W2014090135 hasLocation W20140901351 @default.
• W2014090135 hasLocation W20140901352 @default.
• W2014090135 hasLocation W20140901353 @default.
• W2014090135 hasLocation W20140901354 @default.
• W2014090135 hasOpenAccess W2014090135 @default.
• W2014090135 hasPrimaryLocation W20140901351 @default.
• W2014090135 hasRelatedWork W1970091690 @default.
• W2014090135 hasRelatedWork W2001091301 @default.
• W2014090135 hasRelatedWork W2015559597 @default.
• W2014090135 hasRelatedWork W2053819430 @default.
• W2014090135 hasRelatedWork W2074641809 @default.
• W2014090135 hasRelatedWork W2094990782 @default.

• next