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- W2014094555 abstract "Spontaneously generated calcium (Ca2+) waves can trigger arrhythmias in ventricular and atrial myocytes. Yet, Ca2+ waves also serve the physiological function of mediating global Ca2+ increase and muscle contraction in atrial myocytes. We examine the factors that influence Ca2+ wave initiation by mathematical modeling and large-scale computational (supercomputer) simulations. An important finding is the existence of a strong coupling between the ryanodine receptor distribution and Ca2+ dynamics. Even modest changes in the ryanodine receptor spacing profoundly affect the probability of Ca2+ wave initiation. As a consequence of this finding, we suggest that there is information flow from the contractile system to the Ca2+ control system and this dynamical interplay could contribute to the increased incidence of arrhythmias during heart failure." @default.
- W2014094555 created "2016-06-24" @default.
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- W2014094555 creator A5023763087 @default.
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- W2014094555 date "2006-07-01" @default.
- W2014094555 modified "2023-10-16" @default.
- W2014094555 title "Interplay of Ryanodine Receptor Distribution and Calcium Dynamics" @default.
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- W2014094555 doi "https://doi.org/10.1529/biophysj.105.077214" @default.
- W2014094555 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1479049" @default.
- W2014094555 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16603499" @default.
- W2014094555 hasPublicationYear "2006" @default.
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