FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014096247> ?p ?o ?g. }

• W2014096247 endingPage "300" @default.
• W2014096247 startingPage "293" @default.
• W2014096247 abstract "Manganese (Mn2+)-enhanced magnetic resonance (MR) imaging (MEMRI) in rodents offers unique opportunities for the longitudinal study of hippocampal structure and function in parallel with cognitive testing. However, Mn2+ is a potent toxin and there is evidence that it can interfere with neuronal function. Thus, apart from causing adverse peripheral side effects, Mn2+ may disrupt the function of brain areas where it accumulates to produce signal enhancement and, thereby, Mn2+ administration may confound cognitive testing. Here, we examined in male adult Lister hooded rats if a moderate systemic dose of MnCl2 (200 μmol/kg; two intraperitoneal injections of 100 μmol/kg separated by 1 h) that produces hippocampal MR signal enhancement would disrupt hippocampal function. To this end, we used a delayed-matching-to-place (DMP) watermaze task, which requires rapid allocentric place learning and is highly sensitive to interference with hippocampal function. Tested on the DMP task 1 h and 24 h after MnCl2 injection, rats did not show any impairment in indices of memory performance (latencies, search preference) or any sensorimotor effects. However, MnCl2 injection caused acute peripheral effects (severe ataxia and erythema, i.e. redness of paws, ears, and nose) which subsided over 30 min. Additionally, rats injected with MnCl2 showed reduced weight 1 day after injection and failed to reach the normal weight–growth curve of control rats within the 16 days monitored. Our results indicate that 200 μmol/kg MnCl2 produces hippocampal MR signal enhancement without disrupting hippocampus-dependent behavior on a rapid place learning task, even though attention must be paid to peripheral side effects." @default.
• W2014096247 created "2016-06-24" @default.
• W2014096247 creator A5001454669 @default.
• W2014096247 creator A5020814964 @default.
• W2014096247 creator A5025414398 @default.
• W2014096247 creator A5032871928 @default.
• W2014096247 creator A5048188861 @default.
• W2014096247 creator A5055236752 @default.
• W2014096247 creator A5066168427 @default.
• W2014096247 creator A5068249564 @default.
• W2014096247 date "2011-01-01" @default.
• W2014096247 modified "2023-10-18" @default.
• W2014096247 title "Manganese-enhanced magnetic resonance imaging (MEMRI) of rat brain after systemic administration of MnCl2: Hippocampal signal enhancement without disruption of hippocampus-dependent behavior" @default.
• W2014096247 cites W1531783246 @default.
• W2014096247 cites W1964043050 @default.
• W2014096247 cites W1970835403 @default.
• W2014096247 cites W1972505027 @default.
• W2014096247 cites W1976401241 @default.
• W2014096247 cites W1985901002 @default.
• W2014096247 cites W2007951724 @default.
• W2014096247 cites W2014721161 @default.
• W2014096247 cites W2019243277 @default.
• W2014096247 cites W2022690878 @default.
• W2014096247 cites W2023145239 @default.
• W2014096247 cites W2023932344 @default.
• W2014096247 cites W2030710344 @default.
• W2014096247 cites W2036427824 @default.
• W2014096247 cites W2041583652 @default.
• W2014096247 cites W2042436410 @default.
• W2014096247 cites W2044007321 @default.
• W2014096247 cites W2048413763 @default.
• W2014096247 cites W2049176967 @default.
• W2014096247 cites W2051449111 @default.
• W2014096247 cites W2054886307 @default.
• W2014096247 cites W2062464439 @default.
• W2014096247 cites W2067267086 @default.
• W2014096247 cites W2072412943 @default.
• W2014096247 cites W2073093756 @default.
• W2014096247 cites W2076989525 @default.
• W2014096247 cites W2077612253 @default.
• W2014096247 cites W2078879288 @default.
• W2014096247 cites W2086436391 @default.
• W2014096247 cites W2087484885 @default.
• W2014096247 cites W2091791845 @default.
• W2014096247 cites W2092658381 @default.
• W2014096247 cites W2093360003 @default.
• W2014096247 cites W2095643276 @default.
• W2014096247 cites W2117181706 @default.
• W2014096247 cites W2145132757 @default.
• W2014096247 cites W2148428974 @default.
• W2014096247 cites W2165298588 @default.
• W2014096247 cites W2167266338 @default.
• W2014096247 cites W2469559511 @default.
• W2014096247 doi "https://doi.org/10.1016/j.bbr.2010.08.007" @default.
• W2014096247 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20713092" @default.
• W2014096247 hasPublicationYear "2011" @default.
• W2014096247 type Work @default.
• W2014096247 sameAs 2014096247 @default.
• W2014096247 citedByCount "36" @default.
• W2014096247 countsByYear W20140962472012 @default.
• W2014096247 countsByYear W20140962472013 @default.
• W2014096247 countsByYear W20140962472014 @default.
• W2014096247 countsByYear W20140962472015 @default.
• W2014096247 countsByYear W20140962472016 @default.
• W2014096247 countsByYear W20140962472017 @default.
• W2014096247 countsByYear W20140962472018 @default.
• W2014096247 countsByYear W20140962472020 @default.
• W2014096247 countsByYear W20140962472022 @default.
• W2014096247 crossrefType "journal-article" @default.
• W2014096247 hasAuthorship W2014096247A5001454669 @default.
• W2014096247 hasAuthorship W2014096247A5020814964 @default.
• W2014096247 hasAuthorship W2014096247A5025414398 @default.
• W2014096247 hasAuthorship W2014096247A5032871928 @default.
• W2014096247 hasAuthorship W2014096247A5048188861 @default.
• W2014096247 hasAuthorship W2014096247A5055236752 @default.
• W2014096247 hasAuthorship W2014096247A5066168427 @default.
• W2014096247 hasAuthorship W2014096247A5068249564 @default.
• W2014096247 hasConcept C126322002 @default.
• W2014096247 hasConcept C126838900 @default.
• W2014096247 hasConcept C134018914 @default.
• W2014096247 hasConcept C143409427 @default.
• W2014096247 hasConcept C148762608 @default.
• W2014096247 hasConcept C150903083 @default.
• W2014096247 hasConcept C15744967 @default.
• W2014096247 hasConcept C169760540 @default.
• W2014096247 hasConcept C185592680 @default.
• W2014096247 hasConcept C207001950 @default.
• W2014096247 hasConcept C25938499 @default.
• W2014096247 hasConcept C2779226451 @default.
• W2014096247 hasConcept C2781161787 @default.
• W2014096247 hasConcept C44752575 @default.
• W2014096247 hasConcept C71924100 @default.
• W2014096247 hasConcept C86803240 @default.
• W2014096247 hasConceptScore W2014096247C126322002 @default.
• W2014096247 hasConceptScore W2014096247C126838900 @default.
• W2014096247 hasConceptScore W2014096247C134018914 @default.
• W2014096247 hasConceptScore W2014096247C143409427 @default.
• W2014096247 hasConceptScore W2014096247C148762608 @default.

• next