Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014098055> ?p ?o ?g. }
- W2014098055 endingPage "77" @default.
- W2014098055 startingPage "69" @default.
- W2014098055 abstract "Apolipoprotein E (apoE) is associated with aging and some age-related diseases. The majority of apoE is produced by hepatocytes for the receptor-mediated uptake of lipoproteins. Here, the effects of age on the hepatic expression and distribution of apoE and its receptors were determined using immunofluorescence, Western blots, and quantitative PCR in rat liver tissue and isolated hepatocytes. The expression of apoE mRNA and protein was not influenced significantly by aging. Immunofluorescence studies in isolated hepatocytes showed that apoE was more likely to be co-localized with early endosomes, golgi, and microtubules in isolated old hepatocytes. The mRNA expression of the receptor involved in sequestration of apoE, heparan sulfate proteoglycan was reduced in old age, without any significant effect on the expression of either the low-density lipoprotein receptor or low density-lipoprotein receptor-related protein. Old age is associated with changes in hepatic apoE intracellular trafficking and heparan sulfate proteoglycan expression that might contribute to age-related disease." @default.
- W2014098055 created "2016-06-24" @default.
- W2014098055 creator A5021232751 @default.
- W2014098055 creator A5029257162 @default.
- W2014098055 creator A5059503327 @default.
- W2014098055 creator A5089558075 @default.
- W2014098055 date "2009-10-07" @default.
- W2014098055 modified "2023-09-26" @default.
- W2014098055 title "The effect of old age on apolipoprotein E and its receptors in rat liver" @default.
- W2014098055 cites W1509384892 @default.
- W2014098055 cites W1879810571 @default.
- W2014098055 cites W1904142092 @default.
- W2014098055 cites W1919001607 @default.
- W2014098055 cites W1963783377 @default.
- W2014098055 cites W1966196026 @default.
- W2014098055 cites W1966704916 @default.
- W2014098055 cites W1968475125 @default.
- W2014098055 cites W1975019961 @default.
- W2014098055 cites W1979060271 @default.
- W2014098055 cites W1987029683 @default.
- W2014098055 cites W1987959713 @default.
- W2014098055 cites W1990917840 @default.
- W2014098055 cites W1991386531 @default.
- W2014098055 cites W2007213176 @default.
- W2014098055 cites W2009740188 @default.
- W2014098055 cites W2011359102 @default.
- W2014098055 cites W2030037727 @default.
- W2014098055 cites W2031288523 @default.
- W2014098055 cites W2052908352 @default.
- W2014098055 cites W2065112279 @default.
- W2014098055 cites W2078967765 @default.
- W2014098055 cites W2079920718 @default.
- W2014098055 cites W2084675121 @default.
- W2014098055 cites W2085679502 @default.
- W2014098055 cites W2108244474 @default.
- W2014098055 cites W2121402883 @default.
- W2014098055 cites W2123888680 @default.
- W2014098055 cites W2144863994 @default.
- W2014098055 cites W2156476693 @default.
- W2014098055 cites W2157280645 @default.
- W2014098055 cites W2158731609 @default.
- W2014098055 cites W2158767167 @default.
- W2014098055 cites W4233366116 @default.
- W2014098055 cites W4241874780 @default.
- W2014098055 doi "https://doi.org/10.1007/s11357-009-9115-2" @default.
- W2014098055 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2829642" @default.
- W2014098055 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19809892" @default.
- W2014098055 hasPublicationYear "2009" @default.
- W2014098055 type Work @default.
- W2014098055 sameAs 2014098055 @default.
- W2014098055 citedByCount "10" @default.
- W2014098055 countsByYear W20140980552013 @default.
- W2014098055 countsByYear W20140980552014 @default.
- W2014098055 countsByYear W20140980552020 @default.
- W2014098055 countsByYear W20140980552021 @default.
- W2014098055 crossrefType "journal-article" @default.
- W2014098055 hasAuthorship W2014098055A5021232751 @default.
- W2014098055 hasAuthorship W2014098055A5029257162 @default.
- W2014098055 hasAuthorship W2014098055A5059503327 @default.
- W2014098055 hasAuthorship W2014098055A5089558075 @default.
- W2014098055 hasBestOaLocation W20140980552 @default.
- W2014098055 hasConcept C102747710 @default.
- W2014098055 hasConcept C104317684 @default.
- W2014098055 hasConcept C126322002 @default.
- W2014098055 hasConcept C134018914 @default.
- W2014098055 hasConcept C170493617 @default.
- W2014098055 hasConcept C176891718 @default.
- W2014098055 hasConcept C189165786 @default.
- W2014098055 hasConcept C202751555 @default.
- W2014098055 hasConcept C2776200302 @default.
- W2014098055 hasConcept C2778163477 @default.
- W2014098055 hasConcept C2779134260 @default.
- W2014098055 hasConcept C2779335624 @default.
- W2014098055 hasConcept C2780072125 @default.
- W2014098055 hasConcept C43554185 @default.
- W2014098055 hasConcept C55493867 @default.
- W2014098055 hasConcept C57089818 @default.
- W2014098055 hasConcept C62746215 @default.
- W2014098055 hasConcept C71924100 @default.
- W2014098055 hasConcept C85265743 @default.
- W2014098055 hasConcept C86803240 @default.
- W2014098055 hasConcept C95444343 @default.
- W2014098055 hasConceptScore W2014098055C102747710 @default.
- W2014098055 hasConceptScore W2014098055C104317684 @default.
- W2014098055 hasConceptScore W2014098055C126322002 @default.
- W2014098055 hasConceptScore W2014098055C134018914 @default.
- W2014098055 hasConceptScore W2014098055C170493617 @default.
- W2014098055 hasConceptScore W2014098055C176891718 @default.
- W2014098055 hasConceptScore W2014098055C189165786 @default.
- W2014098055 hasConceptScore W2014098055C202751555 @default.
- W2014098055 hasConceptScore W2014098055C2776200302 @default.
- W2014098055 hasConceptScore W2014098055C2778163477 @default.
- W2014098055 hasConceptScore W2014098055C2779134260 @default.
- W2014098055 hasConceptScore W2014098055C2779335624 @default.
- W2014098055 hasConceptScore W2014098055C2780072125 @default.
- W2014098055 hasConceptScore W2014098055C43554185 @default.
- W2014098055 hasConceptScore W2014098055C55493867 @default.
- W2014098055 hasConceptScore W2014098055C57089818 @default.