FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014099091> ?p ?o ?g. }

• W2014099091 abstract "We characterized morphologic and secretory properties of porcine pancreatic endocrine cells in primary culture obtained by autolytic preparation without any exogenous proteolytic enzymes. The endocrine cells exhibited a neuron-like shape, and insulin granules were accumulated at the terminal of the processes. Thus derived endocrine cells survived in culture medium containing nicotinamide and remained sensitive to glucose for at least 6 weeks after preparations. The cells responded well to physiologic concentrations of glucose, and high K+ depolarization and the antidiabetic sulfonylureas, tolbutamide, and glibenclamide also elicited the release. With high glucose, insulin release was markedly potentiated by forskolin, glucagon, glucagon-like peptide-1, and arginine and inhibited by somatostatin, the Ca2+ channel blocker nitrendipine, and the ATP-sensitive K+ channel opener diazoxide. Epinephrine had dual effects on the release by glucose; enhanced within a low nanomolar range and inhibited at 1 micromol/L. However, the cells were unresponsive to leucine. Such secretory sensitivities to nutrients, hormones, and pharmacologic agents, and long survival rate (as long as 5-6 weeks) of these cells suggest to us therefore that derived endocrine cells may be useful for xenotransplantation of pancreatic beta cells for treatment of insulin-dependent diabetes mellitus." @default.
• W2014099091 created "2016-06-24" @default.
• W2014099091 creator A5021619222 @default.
• W2014099091 creator A5038380963 @default.
• W2014099091 creator A5070183093 @default.
• W2014099091 creator A5078720265 @default.
• W2014099091 creator A5082004548 @default.
• W2014099091 creator A5084473935 @default.
• W2014099091 creator A5089479974 @default.
• W2014099091 date "2001-03-01" @default.
• W2014099091 modified "2023-09-23" @default.
• W2014099091 title "Characterization of Secretory and Morphologic Properties of Primary Cultured Endocrine Cells from Porcine Pancreata" @default.
• W2014099091 cites W1935724085 @default.
• W2014099091 cites W1975742501 @default.
• W2014099091 cites W1980454773 @default.
• W2014099091 cites W1983209489 @default.
• W2014099091 cites W1999580692 @default.
• W2014099091 cites W2005539234 @default.
• W2014099091 cites W2046917110 @default.
• W2014099091 cites W2056018177 @default.
• W2014099091 cites W2070288789 @default.
• W2014099091 cites W2078877235 @default.
• W2014099091 cites W2092803859 @default.
• W2014099091 cites W2100629874 @default.
• W2014099091 cites W2121070699 @default.
• W2014099091 cites W2127112852 @default.
• W2014099091 cites W2335980015 @default.
• W2014099091 cites W2471662575 @default.
• W2014099091 doi "https://doi.org/10.1097/00006676-200103000-00005" @default.
• W2014099091 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11249067" @default.
• W2014099091 hasPublicationYear "2001" @default.
• W2014099091 type Work @default.
• W2014099091 sameAs 2014099091 @default.
• W2014099091 citedByCount "4" @default.
• W2014099091 countsByYear W20140990912014 @default.
• W2014099091 crossrefType "journal-article" @default.
• W2014099091 hasAuthorship W2014099091A5021619222 @default.
• W2014099091 hasAuthorship W2014099091A5038380963 @default.
• W2014099091 hasAuthorship W2014099091A5070183093 @default.
• W2014099091 hasAuthorship W2014099091A5078720265 @default.
• W2014099091 hasAuthorship W2014099091A5082004548 @default.
• W2014099091 hasAuthorship W2014099091A5084473935 @default.
• W2014099091 hasAuthorship W2014099091A5089479974 @default.
• W2014099091 hasConcept C103395026 @default.
• W2014099091 hasConcept C126322002 @default.
• W2014099091 hasConcept C134018914 @default.
• W2014099091 hasConcept C185592680 @default.
• W2014099091 hasConcept C24998067 @default.
• W2014099091 hasConcept C2776054734 @default.
• W2014099091 hasConcept C2776297358 @default.
• W2014099091 hasConcept C2778563252 @default.
• W2014099091 hasConcept C2779276759 @default.
• W2014099091 hasConcept C2779306644 @default.
• W2014099091 hasConcept C2779872217 @default.
• W2014099091 hasConcept C46699223 @default.
• W2014099091 hasConcept C71315377 @default.
• W2014099091 hasConcept C71924100 @default.
• W2014099091 hasConcept C86803240 @default.
• W2014099091 hasConceptScore W2014099091C103395026 @default.
• W2014099091 hasConceptScore W2014099091C126322002 @default.
• W2014099091 hasConceptScore W2014099091C134018914 @default.
• W2014099091 hasConceptScore W2014099091C185592680 @default.
• W2014099091 hasConceptScore W2014099091C24998067 @default.
• W2014099091 hasConceptScore W2014099091C2776054734 @default.
• W2014099091 hasConceptScore W2014099091C2776297358 @default.
• W2014099091 hasConceptScore W2014099091C2778563252 @default.
• W2014099091 hasConceptScore W2014099091C2779276759 @default.
• W2014099091 hasConceptScore W2014099091C2779306644 @default.
• W2014099091 hasConceptScore W2014099091C2779872217 @default.
• W2014099091 hasConceptScore W2014099091C46699223 @default.
• W2014099091 hasConceptScore W2014099091C71315377 @default.
• W2014099091 hasConceptScore W2014099091C71924100 @default.
• W2014099091 hasConceptScore W2014099091C86803240 @default.
• W2014099091 hasLocation W20140990911 @default.
• W2014099091 hasLocation W20140990912 @default.
• W2014099091 hasOpenAccess W2014099091 @default.
• W2014099091 hasPrimaryLocation W20140990911 @default.
• W2014099091 hasRelatedWork W1967347313 @default.
• W2014099091 hasRelatedWork W1968818557 @default.
• W2014099091 hasRelatedWork W1971618815 @default.
• W2014099091 hasRelatedWork W1981191573 @default.
• W2014099091 hasRelatedWork W1987871185 @default.
• W2014099091 hasRelatedWork W1992669990 @default.
• W2014099091 hasRelatedWork W1994013128 @default.
• W2014099091 hasRelatedWork W2004372689 @default.
• W2014099091 hasRelatedWork W2007034510 @default.
• W2014099091 hasRelatedWork W2007565485 @default.
• W2014099091 hasRelatedWork W2010694842 @default.
• W2014099091 hasRelatedWork W2014533862 @default.
• W2014099091 hasRelatedWork W2018840735 @default.
• W2014099091 hasRelatedWork W2019099090 @default.
• W2014099091 hasRelatedWork W2040586076 @default.
• W2014099091 hasRelatedWork W2066108840 @default.
• W2014099091 hasRelatedWork W2089484780 @default.
• W2014099091 hasRelatedWork W2145570537 @default.
• W2014099091 hasRelatedWork W2181476407 @default.
• W2014099091 hasRelatedWork W2394929126 @default.
• W2014099091 isParatext "false" @default.
• W2014099091 isRetracted "false" @default.
• W2014099091 magId "2014099091" @default.

• next