Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014103699> ?p ?o ?g. }
- W2014103699 endingPage "267" @default.
- W2014103699 startingPage "259" @default.
- W2014103699 abstract "Allergic inflammatory responses are driven by cells of the immune system that rely on cytokines to regulate the activity of other immune and structural cells.To review published studies to (1) identify cytokines consistently increased after allergen challenge in atopic patients and (2) investigate temporal variation in cytokine expression.A PUBMED systematic search was used to extract data from studies involving analysis of cytokine expression in fluids or biopsies following in vivo allergen challenge in atopic patients.Data were extracted from 82 studies. There were no consistent reports of cytokine protein increase in fluids of patients at 0-1 h after challenge. At 4-12 h, the chemokines eotaxin, macrophage inflammatory protein-1alpha, RANTES (regulated on activation normal T cell expressed and secreted) and interleukin (IL)-8 have all been consistently reported to be up-regulated. At 18-24 h after challenge, the lymphokines IL-4, IL-5 and IL-13, as well as the pro-inflammatory cytokines granulocyte-macrophage colony-stimulating factor, tumour necrosis factor-alpha and IL-6 are consistently increased when compared with the respective control value. There were no reports of up-regulation in interferon-gamma protein and mRNA and in IL-2 mRNA.The expression of granulocyte-macrophage colony-stimulating factor is consistently increased in tissues at 4-12 h after challenge. The influence of this cytokine on antigen capture and presentation by dendritic cells should be further investigated. Additionally, allergen challenge studies are needed that investigate the expression of macrophage-derived chemokine and thymus-regulated and activation-regulated chemokine in tissues of atopic patients. Blocking the effects of these lymphocyte-specific chemokines might provide new therapeutic approaches for the control of allergic inflammation." @default.
- W2014103699 created "2016-06-24" @default.
- W2014103699 creator A5074490470 @default.
- W2014103699 date "2003-01-01" @default.
- W2014103699 modified "2023-09-27" @default.
- W2014103699 title "Cytokine expression in allergic inflammation: systematic review of<i>in vivo</i>challenge studies" @default.
- W2014103699 cites W14424920 @default.
- W2014103699 cites W149204222 @default.
- W2014103699 cites W1493941926 @default.
- W2014103699 cites W1497022815 @default.
- W2014103699 cites W1511150110 @default.
- W2014103699 cites W1518596541 @default.
- W2014103699 cites W1540207182 @default.
- W2014103699 cites W1560337644 @default.
- W2014103699 cites W1561482026 @default.
- W2014103699 cites W1563336787 @default.
- W2014103699 cites W1563735311 @default.
- W2014103699 cites W1570067081 @default.
- W2014103699 cites W1576499394 @default.
- W2014103699 cites W1579900509 @default.
- W2014103699 cites W1582170718 @default.
- W2014103699 cites W1587557698 @default.
- W2014103699 cites W1601089559 @default.
- W2014103699 cites W1634158134 @default.
- W2014103699 cites W1661544713 @default.
- W2014103699 cites W1705294937 @default.
- W2014103699 cites W1902360293 @default.
- W2014103699 cites W1906051669 @default.
- W2014103699 cites W1907278795 @default.
- W2014103699 cites W1930202916 @default.
- W2014103699 cites W1946129645 @default.
- W2014103699 cites W1963731011 @default.
- W2014103699 cites W1964661356 @default.
- W2014103699 cites W1966264631 @default.
- W2014103699 cites W1967847611 @default.
- W2014103699 cites W1969070743 @default.
- W2014103699 cites W1969912242 @default.
- W2014103699 cites W1969963951 @default.
- W2014103699 cites W1971664259 @default.
- W2014103699 cites W1974187666 @default.
- W2014103699 cites W1974290952 @default.
- W2014103699 cites W1974592243 @default.
- W2014103699 cites W1974649266 @default.
- W2014103699 cites W1979845026 @default.
- W2014103699 cites W1980273468 @default.
- W2014103699 cites W1980604678 @default.
- W2014103699 cites W1981811832 @default.
- W2014103699 cites W1982626106 @default.
- W2014103699 cites W1983798656 @default.
- W2014103699 cites W1984006908 @default.
- W2014103699 cites W1985241518 @default.
- W2014103699 cites W1988074496 @default.
- W2014103699 cites W1988619534 @default.
- W2014103699 cites W1989127266 @default.
- W2014103699 cites W1989504410 @default.
- W2014103699 cites W1990531590 @default.
- W2014103699 cites W1992245040 @default.
- W2014103699 cites W1994362051 @default.
- W2014103699 cites W1995737241 @default.
- W2014103699 cites W1997134658 @default.
- W2014103699 cites W2003528700 @default.
- W2014103699 cites W2003856370 @default.
- W2014103699 cites W2004390098 @default.
- W2014103699 cites W2005142961 @default.
- W2014103699 cites W2009392624 @default.
- W2014103699 cites W2009564102 @default.
- W2014103699 cites W2012480358 @default.
- W2014103699 cites W2012829998 @default.
- W2014103699 cites W2014972792 @default.
- W2014103699 cites W2015827004 @default.
- W2014103699 cites W2017013436 @default.
- W2014103699 cites W2018358366 @default.
- W2014103699 cites W2018669855 @default.
- W2014103699 cites W2021771144 @default.
- W2014103699 cites W2023520187 @default.
- W2014103699 cites W2024885000 @default.
- W2014103699 cites W2026067647 @default.
- W2014103699 cites W2026357145 @default.
- W2014103699 cites W2026708946 @default.
- W2014103699 cites W2027315238 @default.
- W2014103699 cites W2027932154 @default.
- W2014103699 cites W2032029420 @default.
- W2014103699 cites W2032260549 @default.
- W2014103699 cites W2033217491 @default.
- W2014103699 cites W2033528576 @default.
- W2014103699 cites W2034050426 @default.
- W2014103699 cites W2034413866 @default.
- W2014103699 cites W2034475016 @default.
- W2014103699 cites W2036197283 @default.
- W2014103699 cites W2036631709 @default.
- W2014103699 cites W2037439352 @default.
- W2014103699 cites W2038007224 @default.
- W2014103699 cites W2038624559 @default.
- W2014103699 cites W2040836319 @default.
- W2014103699 cites W2041051243 @default.
- W2014103699 cites W2042604341 @default.
- W2014103699 cites W2044530433 @default.
- W2014103699 cites W2045417854 @default.