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• W2014105796 abstract "Biodegradable poly(D,L-lactic acid) nanoparticles loaded with 14C-savoxepine were prepared using a salting-out process avoiding the use of chlorinated solvents and surfactants. Their sustained release properties after intravenous (i.v.) and intramuscular (i.m.) injection were assessed in rats. The pharmacokinetics, excretion and distribution of radioactive substances derived from 14C-savoxepine loaded in particles and as a free test compound in solution were determined by liquid scintillation counting. Particles with a mean diameter of 736 nm and 8.4% compound loading exhibited a sustained release over more than one week. 5.4 days after i.m. injection of the nanoparticles 50% of the initial radioactivity remained in the rats, mainly at the injection site. Stable plasma levels of 14C were observed over 7 days. After injection of the free compound in solution (i.v. or i.m.) 50% of the initial dose of radio-activity was eliminated in less than one day. After i.v. injection of the nanoparticles an effective sustained release was observed. However, the poly (vinyl alcohol) coating of these nanoparticles could not prevent a massive uptake by the reticuloendothelial system." @default.
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• W2014105796 date "1994-02-01" @default.
• W2014105796 modified "2023-10-16" @default.
• W2014105796 title "Distribution, kinetics and elimination of radioactivity after intravenous and intramuscular injection of 14C-savoxepine loaded poly(D,L-lactic acid) nanospheres to rats" @default.
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• W2014105796 doi "https://doi.org/10.1016/0168-3659(94)90125-2" @default.
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