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- W2014113397 abstract "Twelve patients operated on for gall bladder disease under methoxyflurane (Penthrane®) anaesthesia underwent renal function studies pre- and postoperatively. In seven of the patients the concentration of the anaesthetic agent was low, and in five a higher concentration was used. No effect on the glomerular filtration rate (endogenous creatinine clearance) and free water clearance was established. Fractional excretion of sodium decreased highly significantly in the low concentration group, but to a lesser extent in the higher concentration group. This might indicate that there was some effect on the sodium reabsorption in the tubules at methoxyflurane concentrations that were high but still within the normal range. Patients anaesthetized with halothane had a decrease of fractional excretion of sodium of the same order as those patients who received methoxyflurane in high dosage. ZUSAMMENFASSUNG 12 Patienten, die wegen Gallenblasenerkrankung unter Methoxyfluran (Penthran®) operiert wurden, wurden prä- und postoperativ Nierenfunktionsprüfungen unterzogen. Bei 7 der Patienten war die Konzentration des Narkoseanges niedrig, bei 5 wurde eine höhere Konzentration verabreicht. Es zeigte sich keine Wirkung auf die glomuläre Filtrationsrate (endogene Kreatinin-Clearance) und freie Wasser-Clearance. Die anteilige Natrium-Ausscheidung verminderte sich hochsignifikant in der Gruppe mit der niedrigen Konzentration, jedoch in geringerem Ausmaß in der Gruppe der höheren Konzentration. Das könnte dafür sprechen, daß die Natrium-Reabsorption in den Tubulibei hohen, aber noch im Bereich des Gebräuchlichen liegenden Methoxyfluran-Konzentrationen beeinflößt würde. Patienten, welche mit Halothan narkotisiert wurden, wiesen eine Abnahme der anteiligen Natrium-Ausscheidung desselben Ausmaßes auf, wie diese Patienten, die Methoxyfluran in hoher Dosierung erhielten." @default.
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- W2014113397 date "1972-12-01" @default.
- W2014113397 modified "2023-10-05" @default.
- W2014113397 title "The Effect of Methoxyflurane (Penthrane®) on the Renal Function with Special Reference to Tubular Rejection of Sodium" @default.
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- W2014113397 doi "https://doi.org/10.1111/j.1399-6576.1972.tb00976.x" @default.
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