FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014113710> ?p ?o ?g. }

• W2014113710 endingPage "1022" @default.
• W2014113710 startingPage "1010" @default.
• W2014113710 abstract "Several human neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease and Familial Amyloidotic Polyneuropathy, have long been associated with, structural and functional changes in disease related proteins leading to aggregation into amyloid fibrils. Such changes can be triggered by post-translational modifications. Methylglyoxal modifications have been shown to induce the formation of small and stable native-like aggregates in the case of the amyloidogenic proteins insulin and α-synuclein. However, the fundamental biophysical mechanism underlying such methylglyoxal-induced protein aggregation is not yet fully understood. In this work cytochrome c (Cyt c) was used as a model protein for the characterization of specific glycation targets and to study their impact on protein structure, stability, and ability to form native-like aggregates. Our results show that methylglyoxal covalently modifies Cyt c at a single residue and induces early conformational changes that lead to the formation of native-like aggregates. Furthermore, partially unfolded species are formed, but do not seem to be implicated in the aggregation process. This shows a clear difference from the amyloid fibril mechanisms which involve partially or totally unfolded intermediates. Equilibrium-unfolding experiments show that glycation strongly decreases Cyt c conformational stability, which is balanced with an increase of conformational stability upon aggregation. Data collected from analytical and spectroscopic techniques, along with kinetic analysis based on least-squares parameter fitting and statistical model discrimination are used to help to understand the driving force underlying glycation-induced native-like aggregation, and enable the proposal of a comprehensive thermodynamic and kinetic model for native-like aggregation of methylglyoxal glycated Cyt c." @default.
• W2014113710 created "2016-06-24" @default.
• W2014113710 creator A5000298241 @default.
• W2014113710 creator A5000961688 @default.
• W2014113710 creator A5003285664 @default.
• W2014113710 creator A5014508198 @default.
• W2014113710 creator A5040535670 @default.
• W2014113710 creator A5048433029 @default.
• W2014113710 creator A5055862790 @default.
• W2014113710 creator A5063042058 @default.
• W2014113710 creator A5068184462 @default.
• W2014113710 creator A5086362514 @default.
• W2014113710 date "2013-06-01" @default.
• W2014113710 modified "2023-10-03" @default.
• W2014113710 title "Insights into the molecular mechanism of protein native-like aggregation upon glycation" @default.
• W2014113710 cites W1037366320 @default.
• W2014113710 cites W1489708565 @default.
• W2014113710 cites W1503046421 @default.
• W2014113710 cites W1617965928 @default.
• W2014113710 cites W1757241200 @default.
• W2014113710 cites W1927159013 @default.
• W2014113710 cites W1964517967 @default.
• W2014113710 cites W1965384227 @default.
• W2014113710 cites W1965888147 @default.
• W2014113710 cites W1973981695 @default.
• W2014113710 cites W1976528427 @default.
• W2014113710 cites W1995989097 @default.
• W2014113710 cites W1999248724 @default.
• W2014113710 cites W2005279391 @default.
• W2014113710 cites W2006297498 @default.
• W2014113710 cites W2010212854 @default.
• W2014113710 cites W2010754688 @default.
• W2014113710 cites W2013398316 @default.
• W2014113710 cites W2017050373 @default.
• W2014113710 cites W2023840625 @default.
• W2014113710 cites W2024895112 @default.
• W2014113710 cites W2026727321 @default.
• W2014113710 cites W2029208216 @default.
• W2014113710 cites W2032402968 @default.
• W2014113710 cites W2033288419 @default.
• W2014113710 cites W2038263678 @default.
• W2014113710 cites W2042885374 @default.
• W2014113710 cites W2043406394 @default.
• W2014113710 cites W2044108809 @default.
• W2014113710 cites W2047797351 @default.
• W2014113710 cites W2055378374 @default.
• W2014113710 cites W2057709942 @default.
• W2014113710 cites W2058138101 @default.
• W2014113710 cites W2060454311 @default.
• W2014113710 cites W2063096624 @default.
• W2014113710 cites W2070731177 @default.
• W2014113710 cites W2076035297 @default.
• W2014113710 cites W2076162696 @default.
• W2014113710 cites W2076508298 @default.
• W2014113710 cites W2082501707 @default.
• W2014113710 cites W2083310593 @default.
• W2014113710 cites W2097965815 @default.
• W2014113710 cites W2100109707 @default.
• W2014113710 cites W2100851085 @default.
• W2014113710 cites W2100865709 @default.
• W2014113710 cites W2104307385 @default.
• W2014113710 cites W2116076986 @default.
• W2014113710 cites W2117419478 @default.
• W2014113710 cites W2120833123 @default.
• W2014113710 cites W2121176322 @default.
• W2014113710 cites W2140260269 @default.
• W2014113710 cites W2142635246 @default.
• W2014113710 cites W2153456067 @default.
• W2014113710 cites W2153998719 @default.
• W2014113710 cites W2158640432 @default.
• W2014113710 cites W2161713694 @default.
• W2014113710 cites W2165186407 @default.
• W2014113710 cites W2168994316 @default.
• W2014113710 cites W2171526610 @default.
• W2014113710 doi "https://doi.org/10.1016/j.bbapap.2012.12.001" @default.
• W2014113710 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23228929" @default.
• W2014113710 hasPublicationYear "2013" @default.
• W2014113710 type Work @default.
• W2014113710 sameAs 2014113710 @default.
• W2014113710 citedByCount "48" @default.
• W2014113710 countsByYear W20141137102013 @default.
• W2014113710 countsByYear W20141137102014 @default.
• W2014113710 countsByYear W20141137102015 @default.
• W2014113710 countsByYear W20141137102016 @default.
• W2014113710 countsByYear W20141137102017 @default.
• W2014113710 countsByYear W20141137102018 @default.
• W2014113710 countsByYear W20141137102019 @default.
• W2014113710 countsByYear W20141137102020 @default.
• W2014113710 countsByYear W20141137102021 @default.
• W2014113710 countsByYear W20141137102022 @default.
• W2014113710 countsByYear W20141137102023 @default.
• W2014113710 crossrefType "journal-article" @default.
• W2014113710 hasAuthorship W2014113710A5000298241 @default.
• W2014113710 hasAuthorship W2014113710A5000961688 @default.
• W2014113710 hasAuthorship W2014113710A5003285664 @default.
• W2014113710 hasAuthorship W2014113710A5014508198 @default.
• W2014113710 hasAuthorship W2014113710A5040535670 @default.
• W2014113710 hasAuthorship W2014113710A5048433029 @default.

• next