Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014114825> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W2014114825 abstract "We examined the metabolism of N-desisopropylpropranolol (NDP), which is generated from propranolol (PL) by side-chain N-desisopropylation, to naphthoxylactic acid (NLA) in rat liver. S(-)-NDP (S-NDP) and R(+)-NDP (R-NDP) were enantioselectively metabolized to NLA in isolated rat hepatocytes and in an enzyme reaction system of rat liver mitochondria with cofactor NAD+. Furthermore, the clearance profiles of NDP enantiomers were examined in an enzyme reaction system of rat liver mitochondria without NAD+. The amounts of S-NDP remaining in the incubation medium were similar to those of R-NDP, suggesting that monoamine oxidase (MAO) catalyzes the deamination of NDP to the aldehyde intermediate, but fails to deaminate enantioselectively S-NDP or R-NDP. Cyanamide, a potent inhibitor of aldehyde dehydrogenase (ALDH), markedly decreased the formation of NLA from racemic NDP in the enzyme reaction system of rat liver mitochondria with NAD+. When rat liver cytosol and microsomes were added to this enzyme reaction system, no significant alterations were observed in the amount of NLA generated from racemic NDP. We concluded that MAO deaminates NDP to an aldehyde intermediate, and that mitochondrial ALDH subsequently catalyzes the enantioselective metabolism of the aldehyde intermediate to NLA in rat liver." @default.
- W2014114825 created "2016-06-24" @default.
- W2014114825 creator A5013631887 @default.
- W2014114825 creator A5013857943 @default.
- W2014114825 creator A5061634245 @default.
- W2014114825 creator A5084863691 @default.
- W2014114825 date "2002-04-01" @default.
- W2014114825 modified "2023-09-25" @default.
- W2014114825 title "Side-chain metabolism of propranolol: involvement of monoamine oxidase and mitochondrial aldehyde dehydrogenase in the metabolism of N-desisopropylpropranolol to naphthoxylactic acid in rat liver" @default.
- W2014114825 cites W1921020344 @default.
- W2014114825 cites W1966907248 @default.
- W2014114825 cites W1977152396 @default.
- W2014114825 cites W1979243197 @default.
- W2014114825 cites W2001342878 @default.
- W2014114825 cites W2010011856 @default.
- W2014114825 cites W2012694008 @default.
- W2014114825 cites W2028872385 @default.
- W2014114825 cites W2035121831 @default.
- W2014114825 cites W2042594625 @default.
- W2014114825 cites W2055942661 @default.
- W2014114825 cites W2065919576 @default.
- W2014114825 cites W2074421061 @default.
- W2014114825 cites W2298207820 @default.
- W2014114825 doi "https://doi.org/10.1016/s0024-3205(02)01540-0" @default.
- W2014114825 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12269395" @default.
- W2014114825 hasPublicationYear "2002" @default.
- W2014114825 type Work @default.
- W2014114825 sameAs 2014114825 @default.
- W2014114825 citedByCount "7" @default.
- W2014114825 countsByYear W20141148252013 @default.
- W2014114825 countsByYear W20141148252020 @default.
- W2014114825 countsByYear W20141148252021 @default.
- W2014114825 crossrefType "journal-article" @default.
- W2014114825 hasAuthorship W2014114825A5013631887 @default.
- W2014114825 hasAuthorship W2014114825A5013857943 @default.
- W2014114825 hasAuthorship W2014114825A5061634245 @default.
- W2014114825 hasAuthorship W2014114825A5084863691 @default.
- W2014114825 hasConcept C181199279 @default.
- W2014114825 hasConcept C185592680 @default.
- W2014114825 hasConcept C25747580 @default.
- W2014114825 hasConcept C2776024655 @default.
- W2014114825 hasConcept C2778102346 @default.
- W2014114825 hasConcept C2779840689 @default.
- W2014114825 hasConcept C28859421 @default.
- W2014114825 hasConcept C3175096 @default.
- W2014114825 hasConcept C55493867 @default.
- W2014114825 hasConcept C62231903 @default.
- W2014114825 hasConcept C75520062 @default.
- W2014114825 hasConcept C86803240 @default.
- W2014114825 hasConcept C87644729 @default.
- W2014114825 hasConceptScore W2014114825C181199279 @default.
- W2014114825 hasConceptScore W2014114825C185592680 @default.
- W2014114825 hasConceptScore W2014114825C25747580 @default.
- W2014114825 hasConceptScore W2014114825C2776024655 @default.
- W2014114825 hasConceptScore W2014114825C2778102346 @default.
- W2014114825 hasConceptScore W2014114825C2779840689 @default.
- W2014114825 hasConceptScore W2014114825C28859421 @default.
- W2014114825 hasConceptScore W2014114825C3175096 @default.
- W2014114825 hasConceptScore W2014114825C55493867 @default.
- W2014114825 hasConceptScore W2014114825C62231903 @default.
- W2014114825 hasConceptScore W2014114825C75520062 @default.
- W2014114825 hasConceptScore W2014114825C86803240 @default.
- W2014114825 hasConceptScore W2014114825C87644729 @default.
- W2014114825 hasLocation W20141148251 @default.
- W2014114825 hasLocation W20141148252 @default.
- W2014114825 hasOpenAccess W2014114825 @default.
- W2014114825 hasPrimaryLocation W20141148251 @default.
- W2014114825 hasRelatedWork W179617147 @default.
- W2014114825 hasRelatedWork W1942283438 @default.
- W2014114825 hasRelatedWork W1995986479 @default.
- W2014114825 hasRelatedWork W2000663266 @default.
- W2014114825 hasRelatedWork W2002626915 @default.
- W2014114825 hasRelatedWork W2028177598 @default.
- W2014114825 hasRelatedWork W2030604989 @default.
- W2014114825 hasRelatedWork W2041074077 @default.
- W2014114825 hasRelatedWork W2047522969 @default.
- W2014114825 hasRelatedWork W2052962124 @default.
- W2014114825 hasRelatedWork W2058167835 @default.
- W2014114825 hasRelatedWork W2104604555 @default.
- W2014114825 hasRelatedWork W2187049545 @default.
- W2014114825 hasRelatedWork W2254063816 @default.
- W2014114825 hasRelatedWork W2315419554 @default.
- W2014114825 hasRelatedWork W2350379400 @default.
- W2014114825 hasRelatedWork W2406102398 @default.
- W2014114825 hasRelatedWork W2407204043 @default.
- W2014114825 hasRelatedWork W2987558704 @default.
- W2014114825 hasRelatedWork W3104277554 @default.
- W2014114825 isParatext "false" @default.
- W2014114825 isRetracted "false" @default.
- W2014114825 magId "2014114825" @default.
- W2014114825 workType "article" @default.