FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014114932> ?p ?o ?g. }

• W2014114932 endingPage "353" @default.
• W2014114932 startingPage "345" @default.
• W2014114932 abstract "Neural development involves the expression of ensembles of regulatory genes that control the coordinate and region-specific expression of a host of other genes, resulting in the unique structure, connectivity, and function of each brain region. Although the role of some specific genes in neural development has been studied in detail, we have no global view of the orchestration of spatial and temporal aspects of gene expression across multiple regions of the developing brain. To this end, we used transcriptional profiling to examine expression levels of 9955 genes in the hypothalamus, hippocampus, and frontal cortex across seven stages of postnatal development and up to four stages of prenatal development in individual male rats (six per group). The results reveal dramatic changes across development in >97% of the neurally expressed genes. They also uncover a surprising degree of regional differentiation occurring after birth and through the first 2 weeks of life. Cluster analysis identifies 20 clusters of transcripts enriched in genes related to particular functions, such as DNA metabolism, nuclear function, synaptic vesicle transport, myelination, and neuropeptide hormone activity. Thus, groups of genes with related functions change in the brain at specific times, possibly marking critical periods for each function. These findings can broadly serve as a backdrop for studying the role of individual genes in neural development. They also underscore the importance of early postnatal life in the rat, which corresponds to late gestation in the human, as a critical late phase of neural organization and differentiation, even in subcortical regions." @default.
• W2014114932 created "2016-06-24" @default.
• W2014114932 creator A5007964297 @default.
• W2014114932 creator A5021615086 @default.
• W2014114932 creator A5021936585 @default.
• W2014114932 creator A5038907597 @default.
• W2014114932 creator A5049286080 @default.
• W2014114932 creator A5062171172 @default.
• W2014114932 creator A5078403031 @default.
• W2014114932 creator A5084113291 @default.
• W2014114932 date "2006-01-04" @default.
• W2014114932 modified "2023-09-23" @default.
• W2014114932 title "Transcriptional Profiling of the Developing Rat Brain Reveals That the Most Dramatic Regional Differentiation in Gene Expression Occurs Postpartum" @default.
• W2014114932 cites W125412302 @default.
• W2014114932 cites W1535233600 @default.
• W2014114932 cites W1541267199 @default.
• W2014114932 cites W1975939971 @default.
• W2014114932 cites W1981719311 @default.
• W2014114932 cites W1994425505 @default.
• W2014114932 cites W2000209446 @default.
• W2014114932 cites W2001382581 @default.
• W2014114932 cites W2002444757 @default.
• W2014114932 cites W2003982930 @default.
• W2014114932 cites W2017069041 @default.
• W2014114932 cites W2026314174 @default.
• W2014114932 cites W2028592029 @default.
• W2014114932 cites W2036386442 @default.
• W2014114932 cites W2037383099 @default.
• W2014114932 cites W2039358114 @default.
• W2014114932 cites W2044935982 @default.
• W2014114932 cites W2048614428 @default.
• W2014114932 cites W2049735743 @default.
• W2014114932 cites W2051420506 @default.
• W2014114932 cites W2052536256 @default.
• W2014114932 cites W2060960668 @default.
• W2014114932 cites W2065736161 @default.
• W2014114932 cites W2092148873 @default.
• W2014114932 cites W2096693435 @default.
• W2014114932 cites W2100793213 @default.
• W2014114932 cites W2101014059 @default.
• W2014114932 cites W2108334325 @default.
• W2014114932 cites W2109972881 @default.
• W2014114932 cites W2113083842 @default.
• W2014114932 cites W2116265489 @default.
• W2014114932 cites W2118439943 @default.
• W2014114932 cites W2120095635 @default.
• W2014114932 cites W2124248841 @default.
• W2014114932 cites W2134711325 @default.
• W2014114932 cites W2135827569 @default.
• W2014114932 cites W2139913482 @default.
• W2014114932 cites W2141124547 @default.
• W2014114932 cites W2148300596 @default.
• W2014114932 cites W2149570279 @default.
• W2014114932 cites W2150092716 @default.
• W2014114932 cites W2162196924 @default.
• W2014114932 cites W2233634715 @default.
• W2014114932 cites W2320983896 @default.
• W2014114932 cites W4252486266 @default.
• W2014114932 doi "https://doi.org/10.1523/jneurosci.2755-05.2006" @default.
• W2014114932 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6674315" @default.
• W2014114932 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16399705" @default.
• W2014114932 hasPublicationYear "2006" @default.
• W2014114932 type Work @default.
• W2014114932 sameAs 2014114932 @default.
• W2014114932 citedByCount "93" @default.
• W2014114932 countsByYear W20141149322012 @default.
• W2014114932 countsByYear W20141149322013 @default.
• W2014114932 countsByYear W20141149322014 @default.
• W2014114932 countsByYear W20141149322015 @default.
• W2014114932 countsByYear W20141149322016 @default.
• W2014114932 countsByYear W20141149322017 @default.
• W2014114932 countsByYear W20141149322018 @default.
• W2014114932 countsByYear W20141149322019 @default.
• W2014114932 countsByYear W20141149322020 @default.
• W2014114932 countsByYear W20141149322021 @default.
• W2014114932 countsByYear W20141149322023 @default.
• W2014114932 crossrefType "journal-article" @default.
• W2014114932 hasAuthorship W2014114932A5007964297 @default.
• W2014114932 hasAuthorship W2014114932A5021615086 @default.
• W2014114932 hasAuthorship W2014114932A5021936585 @default.
• W2014114932 hasAuthorship W2014114932A5038907597 @default.
• W2014114932 hasAuthorship W2014114932A5049286080 @default.
• W2014114932 hasAuthorship W2014114932A5062171172 @default.
• W2014114932 hasAuthorship W2014114932A5078403031 @default.
• W2014114932 hasAuthorship W2014114932A5084113291 @default.
• W2014114932 hasBestOaLocation W20141149321 @default.
• W2014114932 hasConcept C104317684 @default.
• W2014114932 hasConcept C150194340 @default.
• W2014114932 hasConcept C165864922 @default.
• W2014114932 hasConcept C169760540 @default.
• W2014114932 hasConcept C18431079 @default.
• W2014114932 hasConcept C461258 @default.
• W2014114932 hasConcept C54355233 @default.
• W2014114932 hasConcept C63405245 @default.
• W2014114932 hasConcept C86803240 @default.
• W2014114932 hasConceptScore W2014114932C104317684 @default.
• W2014114932 hasConceptScore W2014114932C150194340 @default.
• W2014114932 hasConceptScore W2014114932C165864922 @default.

• next