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- W2014115912 abstract "Purpose Leucocytopenia (LCP) ( μ 1) in breast cancer patients treated by adjuvant chemotherapy (CT) is an excepted side effect. In contrast radiation (RT) induced LCP in postoperatively irradiated breast carcinoma is unusual. We analysed the incidence of RT induced LCP and possible reasons of its occurrence. Patients From 1989–93 185 patients with primary breast carcinoma (T1–4N0–2 MO) were treated by surgery alone (n = 87), by additional CT with CMF (n = 10), by postoperative RT only (chest wall/breast and/or regional lymph nodes) (n = 54) or by all three modalities (n = 36). All groups were comparable with regard to age. Blood examinations were performed once weekly. Results LCP was observed in women treated by surgery alone in 4.6%, by surgery and CT in 60%, by postoperative RT in 31.5% and by combined procedure in 88.9%. In all irradiated women (n = 90) leucocytes counts were lower than in those without RT ( P = 0.001). In contrast to chest wall/breast irradiation alone, all patients treated by CT and RT of the chest wall/breast including regional lymph nodes revealed decreasing leucocytes counts ( P = 0.003). Conclusions Our data suggest that the size of irradiated volume can significantly enhance the risk of LCP in primary breast cancer patients treated by CT. Our results enable to define criteria necessary for selection of patients with recommended frequent blood examinations." @default.
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- W2014115912 date "1995-11-01" @default.
- W2014115912 modified "2023-09-24" @default.
- W2014115912 title "63 Incidence and causes of leucocytopenia in post-operatively irradiated breast cancer patients" @default.
- W2014115912 doi "https://doi.org/10.1016/0959-8049(95)95315-w" @default.
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