Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014118522> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W2014118522 endingPage "301" @default.
- W2014118522 startingPage "295" @default.
- W2014118522 abstract "Experiments were performed to explore the ability of murine cytomegalovirus (MCMV) to disseminate to the eye following intravenous inoculation and to cause infection of ocular tissues and necrotizing retinitis in C57BL/6 mice with retrovirus-induced immunodeficiency syndrome (MAIDS). Although infectious virus could be detected in whole eye homogenates of mice with MAIDS at 10 days after intravenous MCMV inoculation, a recombinant MCMV (RM461) that carries an MCMV IE1 promoter-LacZ insert was used as a tracer virus to confirm direct infection of ocular tissues. Evidence for MCMV replication (determined by RM461-induced expression of beta-galactosidase) was consistently observed in the nonpigmented epithelium of the ciliary body of the eyes of MAIDS animals at 14 days after infection. In sharp contrast, however, the neurosensory retina was spared and necrotizing retinitis failed to develop. These findings demonstrate that systemic MCMV infection of mice with MAIDS results in ocular MCMV infection without development of ocular MCMV disease. Conversion of occult subclinical MCMV infection of ocular tissues to overt clinical MCMV retinitis may require as yet unidentified cofactor(s). Identification of these cofactors could lead to more innovative therapeutic approaches for prevention and/or treatment of CMV retinitis in patients with AIDS." @default.
- W2014118522 created "2016-06-24" @default.
- W2014118522 creator A5033299144 @default.
- W2014118522 date "1998-01-01" @default.
- W2014118522 modified "2023-10-18" @default.
- W2014118522 title "Systemic Murine Cytomegalovirus Infection of Mice with Retrovirus- Induced Immunodeficiency Results in Ocular Infection but Not Retinitis" @default.
- W2014118522 cites W10176543 @default.
- W2014118522 cites W1508861844 @default.
- W2014118522 cites W175866339 @default.
- W2014118522 cites W1980035786 @default.
- W2014118522 cites W2059289017 @default.
- W2014118522 cites W2070793492 @default.
- W2014118522 cites W2091281345 @default.
- W2014118522 cites W2098746214 @default.
- W2014118522 cites W2519150737 @default.
- W2014118522 cites W40102595 @default.
- W2014118522 cites W43036852 @default.
- W2014118522 cites W182682368 @default.
- W2014118522 doi "https://doi.org/10.1159/000055488" @default.
- W2014118522 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9704333" @default.
- W2014118522 hasPublicationYear "1998" @default.
- W2014118522 type Work @default.
- W2014118522 sameAs 2014118522 @default.
- W2014118522 citedByCount "13" @default.
- W2014118522 countsByYear W20141185222012 @default.
- W2014118522 countsByYear W20141185222017 @default.
- W2014118522 countsByYear W20141185222018 @default.
- W2014118522 countsByYear W20141185222019 @default.
- W2014118522 countsByYear W20141185222021 @default.
- W2014118522 crossrefType "journal-article" @default.
- W2014118522 hasAuthorship W2014118522A5033299144 @default.
- W2014118522 hasConcept C113280763 @default.
- W2014118522 hasConcept C159047783 @default.
- W2014118522 hasConcept C203014093 @default.
- W2014118522 hasConcept C2522874641 @default.
- W2014118522 hasConcept C2776185481 @default.
- W2014118522 hasConcept C2776409557 @default.
- W2014118522 hasConcept C2777016524 @default.
- W2014118522 hasConcept C2777324356 @default.
- W2014118522 hasConcept C2777607303 @default.
- W2014118522 hasConcept C2777732132 @default.
- W2014118522 hasConcept C2779820661 @default.
- W2014118522 hasConcept C2780727368 @default.
- W2014118522 hasConcept C71924100 @default.
- W2014118522 hasConcept C86803240 @default.
- W2014118522 hasConcept C8891405 @default.
- W2014118522 hasConceptScore W2014118522C113280763 @default.
- W2014118522 hasConceptScore W2014118522C159047783 @default.
- W2014118522 hasConceptScore W2014118522C203014093 @default.
- W2014118522 hasConceptScore W2014118522C2522874641 @default.
- W2014118522 hasConceptScore W2014118522C2776185481 @default.
- W2014118522 hasConceptScore W2014118522C2776409557 @default.
- W2014118522 hasConceptScore W2014118522C2777016524 @default.
- W2014118522 hasConceptScore W2014118522C2777324356 @default.
- W2014118522 hasConceptScore W2014118522C2777607303 @default.
- W2014118522 hasConceptScore W2014118522C2777732132 @default.
- W2014118522 hasConceptScore W2014118522C2779820661 @default.
- W2014118522 hasConceptScore W2014118522C2780727368 @default.
- W2014118522 hasConceptScore W2014118522C71924100 @default.
- W2014118522 hasConceptScore W2014118522C86803240 @default.
- W2014118522 hasConceptScore W2014118522C8891405 @default.
- W2014118522 hasIssue "5" @default.
- W2014118522 hasLocation W20141185221 @default.
- W2014118522 hasLocation W20141185222 @default.
- W2014118522 hasOpenAccess W2014118522 @default.
- W2014118522 hasPrimaryLocation W20141185221 @default.
- W2014118522 hasRelatedWork W2006623749 @default.
- W2014118522 hasRelatedWork W2073136628 @default.
- W2014118522 hasRelatedWork W2090281443 @default.
- W2014118522 hasRelatedWork W2139314005 @default.
- W2014118522 hasRelatedWork W2143373515 @default.
- W2014118522 hasRelatedWork W2148409327 @default.
- W2014118522 hasRelatedWork W2153919602 @default.
- W2014118522 hasRelatedWork W2394926923 @default.
- W2014118522 hasRelatedWork W2521324443 @default.
- W2014118522 hasRelatedWork W4249253247 @default.
- W2014118522 hasVolume "30" @default.
- W2014118522 isParatext "false" @default.
- W2014118522 isRetracted "false" @default.
- W2014118522 magId "2014118522" @default.
- W2014118522 workType "article" @default.