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- W2014121911 abstract "A number of lipophilic nitrogenous bases, designed to act as membrane-active, catalytic proton transfer agents, were tested for their ability to neutralize the acidity of lysosomes, a model for other acidic intracellular vesicles involved in drug sorting. The most successful of these, an imidazole 1, caused a 1.7 unit rise in lysosomal pH of RAW cells at 100 microM, compared to a 0.2 and 1.4 unit rise for ammonium chloride at 100 microM and 10 mM, respectively. Compound 1 also exhibited potent reversal of doxorubicin (DOX) resistance in the HCT116-VM46 cell line by a factor of 14 over the sensitive strain, and superior to that of widely used verapamil (VRP) by a factor of 1.75 at 20 microM. It also has antiviral properties, and potential applications in other lysosome-related areas such as immunotoxin potentiation and the control of bacterial toxins, immune response, prion replication, malaria and intralysosomal microorganisms." @default.
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- W2014121911 date "1994-04-01" @default.
- W2014121911 modified "2023-09-23" @default.
- W2014121911 title "Reversal of doxorubicin resistance and catalytic neutralization of lysosomes by a lipophilic imidazole" @default.
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- W2014121911 doi "https://doi.org/10.1016/0005-2736(94)90237-2" @default.
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