FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014123062> ?p ?o ?g. }

• W2014123062 endingPage "230" @default.
• W2014123062 startingPage "223" @default.
• W2014123062 abstract "Androgenic disorders of female skin such as hirsutism, acne and alopecia are etiologically caused by androgen excess. Skin 5 alpha-reductase activity is a major factor influencing the manifestation of endogenous androgen excess in women. Oral contraceptives have proven useful for the treatment of androgen disorders of the skin. The mechanisms of action by which oral contraceptives correct skin androgen levels may include inhibition of 5 alpha-reductase and androgen receptor activity. We investigated the inhibitory effect of oral contraceptive progestins and ethinyl estradiol on skin 5 alpha-reductase and their influence on androgen receptor activity and affinity, using three different in vitro assay systems. It was shown that norgestimate blocked 5 alpha-reductase activity with an IC50 value of 10 microM, followed by levonorgestrel (IC50 52 microM), dienogest (IC50 55 microM), cyproterone acetate (IC50 87 microM) and gestodene (IC50 98 microM). To determine the full androgenic potential of the progestins, androgen receptor binding affinities and activation potentials were determined. The progestins norgestimate and dienogest in particular combined 5 alpha-reductase inhibition with minimal androgenic potential. These data demonstrate that the progestins norgestimate and dienogest might help in the treatment of clinical hyperandrogeny in women." @default.
• W2014123062 created "2016-06-24" @default.
• W2014123062 creator A5016663585 @default.
• W2014123062 creator A5042756729 @default.
• W2014123062 creator A5085253505 @default.
• W2014123062 creator A5085837732 @default.
• W2014123062 date "2000-01-01" @default.
• W2014123062 modified "2023-09-25" @default.
• W2014123062 title "Inhibition of skin 5α-reductase by oral contraceptive progestins<i>in vitro</i>" @default.
• W2014123062 cites W1484051386 @default.
• W2014123062 cites W1576798844 @default.
• W2014123062 cites W1968449473 @default.
• W2014123062 cites W1977377601 @default.
• W2014123062 cites W1981535508 @default.
• W2014123062 cites W1982639927 @default.
• W2014123062 cites W1986075506 @default.
• W2014123062 cites W1987160428 @default.
• W2014123062 cites W1989712846 @default.
• W2014123062 cites W2000646213 @default.
• W2014123062 cites W2003982276 @default.
• W2014123062 cites W2022065845 @default.
• W2014123062 cites W2034412478 @default.
• W2014123062 cites W2038479139 @default.
• W2014123062 cites W2041674416 @default.
• W2014123062 cites W2042673690 @default.
• W2014123062 cites W2050567539 @default.
• W2014123062 cites W2066667129 @default.
• W2014123062 cites W2079083023 @default.
• W2014123062 cites W2082528130 @default.
• W2014123062 cites W2089688362 @default.
• W2014123062 cites W2106515985 @default.
• W2014123062 cites W2110856334 @default.
• W2014123062 cites W2130180306 @default.
• W2014123062 cites W2131353173 @default.
• W2014123062 cites W2143917623 @default.
• W2014123062 cites W2149588900 @default.
• W2014123062 cites W23505623 @default.
• W2014123062 cites W4233789535 @default.
• W2014123062 cites W4293247451 @default.
• W2014123062 cites W44170139 @default.
• W2014123062 cites W66458291 @default.
• W2014123062 doi "https://doi.org/10.3109/09513590009167685" @default.
• W2014123062 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11075290" @default.
• W2014123062 hasPublicationYear "2000" @default.
• W2014123062 type Work @default.
• W2014123062 sameAs 2014123062 @default.
• W2014123062 citedByCount "78" @default.
• W2014123062 countsByYear W20141230622012 @default.
• W2014123062 countsByYear W20141230622013 @default.
• W2014123062 countsByYear W20141230622014 @default.
• W2014123062 countsByYear W20141230622015 @default.
• W2014123062 countsByYear W20141230622016 @default.
• W2014123062 countsByYear W20141230622017 @default.
• W2014123062 countsByYear W20141230622018 @default.
• W2014123062 countsByYear W20141230622019 @default.
• W2014123062 countsByYear W20141230622020 @default.
• W2014123062 countsByYear W20141230622021 @default.
• W2014123062 countsByYear W20141230622022 @default.
• W2014123062 countsByYear W20141230622023 @default.
• W2014123062 crossrefType "journal-article" @default.
• W2014123062 hasAuthorship W2014123062A5016663585 @default.
• W2014123062 hasAuthorship W2014123062A5042756729 @default.
• W2014123062 hasAuthorship W2014123062A5085253505 @default.
• W2014123062 hasAuthorship W2014123062A5085837732 @default.
• W2014123062 hasConcept C121608353 @default.
• W2014123062 hasConcept C126322002 @default.
• W2014123062 hasConcept C134018914 @default.
• W2014123062 hasConcept C185592680 @default.
• W2014123062 hasConcept C2775874879 @default.
• W2014123062 hasConcept C2776235491 @default.
• W2014123062 hasConcept C2776607906 @default.
• W2014123062 hasConcept C2777155358 @default.
• W2014123062 hasConcept C2777164284 @default.
• W2014123062 hasConcept C2777911890 @default.
• W2014123062 hasConcept C2778239997 @default.
• W2014123062 hasConcept C2779076696 @default.
• W2014123062 hasConcept C2779279991 @default.
• W2014123062 hasConcept C2779522080 @default.
• W2014123062 hasConcept C2779881493 @default.
• W2014123062 hasConcept C2780192828 @default.
• W2014123062 hasConcept C2781418897 @default.
• W2014123062 hasConcept C2908647359 @default.
• W2014123062 hasConcept C2910366748 @default.
• W2014123062 hasConcept C2986817661 @default.
• W2014123062 hasConcept C61367390 @default.
• W2014123062 hasConcept C71315377 @default.
• W2014123062 hasConcept C71924100 @default.
• W2014123062 hasConcept C98274493 @default.
• W2014123062 hasConcept C99454951 @default.
• W2014123062 hasConceptScore W2014123062C121608353 @default.
• W2014123062 hasConceptScore W2014123062C126322002 @default.
• W2014123062 hasConceptScore W2014123062C134018914 @default.
• W2014123062 hasConceptScore W2014123062C185592680 @default.
• W2014123062 hasConceptScore W2014123062C2775874879 @default.
• W2014123062 hasConceptScore W2014123062C2776235491 @default.
• W2014123062 hasConceptScore W2014123062C2776607906 @default.
• W2014123062 hasConceptScore W2014123062C2777155358 @default.
• W2014123062 hasConceptScore W2014123062C2777164284 @default.

• next