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- W2014129968 abstract "The synthesis, antimicrobial activity, and binding to ribosomes of leucomycin and leucomycin derivatives are described. In general, the binding of the leucomycins and the leucomycin derivatives to ribosomes correlated with their antimicrobial activity. Some 2'-O-acyl derivatives apparently underwent gradual hydrolysis during antimicrobial assays, for their binding to ribosomes was poor compared to their relatively good antimicrobial activies. Correlation between antimicrobial activity and binding to ribosomes, their molecular site of action, provides some insight into the nature of the active molecular moieties." @default.
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- W2014129968 date "1977-05-01" @default.
- W2014129968 modified "2023-10-18" @default.
- W2014129968 title "Structure-activity relations among the O-acyl derivatives of leucomycin. Correlation of minimal inhibitory concentrations with binding to Escherichia coli ribosomes" @default.
- W2014129968 doi "https://doi.org/10.1021/jm00215a025" @default.
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