Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014133909> ?p ?o ?g. }
- W2014133909 endingPage "671" @default.
- W2014133909 startingPage "660" @default.
- W2014133909 abstract "The control of DNA integrity in mammalian cells is important to maintain the cell homeostasis and prevent neoplastic transformation. Control of cell division and cell death permits repair or elimination of damaged cells. Since asbestos fibers can produce DNA damage, chromosome alterations and apoptosis in several sorts of cells, including mesothelial cells, it was interesting to investigate cell cycle disturbances in rat pleural mesothelial cells (RPMC) treated with asbestos fibers. Cell cycle analyses were performed in RPMC exposed to crocidolite (10 and 20 microg/cm2) and chrysotile (5 and 10 microg/cm2) for different times (4 to 48 h). Both fiber types entailed a G2/M accumulation in agreement with a delay in the mitosis course. Chrysotile fibers produced a G0/G1 accumulation associated with a time-dependent p53 and p21 expression. Crocidolite exposure resulted in a delay in the G1/S transition paralleling a low rate of p53 expression. These results are in agreement with a DNA damaging potential of asbestos fibers since similar results were found following RPMC exposure to gamma rays. In asbestos-treated RPMC, a low rate of apoptosis was found suggesting that RPMC may follow a DNA repair pathway that could contribute to the formation of DNA lesions. In addition, the cell cycle disturbances at the G2/M checkpoint suggest that genetically altered cells have progressed through the cycle and support the already published findings on the ability of asbestos fibers to impair cell division." @default.
- W2014133909 created "2016-06-24" @default.
- W2014133909 creator A5002232142 @default.
- W2014133909 creator A5017502198 @default.
- W2014133909 creator A5017547671 @default.
- W2014133909 creator A5023904607 @default.
- W2014133909 creator A5050755009 @default.
- W2014133909 creator A5057592396 @default.
- W2014133909 creator A5062003491 @default.
- W2014133909 creator A5088709075 @default.
- W2014133909 date "1997-12-01" @default.
- W2014133909 modified "2023-10-17" @default.
- W2014133909 title "Analysis of Cell Cycle Disruptions in Cultures of Rat Pleural Mesothelial Cells Exposed to Asbestos Fibers" @default.
- W2014133909 cites W1869449658 @default.
- W2014133909 cites W1969385456 @default.
- W2014133909 cites W1970546664 @default.
- W2014133909 cites W1971622089 @default.
- W2014133909 cites W1971928705 @default.
- W2014133909 cites W1976532982 @default.
- W2014133909 cites W1977720361 @default.
- W2014133909 cites W1979960573 @default.
- W2014133909 cites W1981488919 @default.
- W2014133909 cites W1991736202 @default.
- W2014133909 cites W2012323141 @default.
- W2014133909 cites W2017047165 @default.
- W2014133909 cites W2020821484 @default.
- W2014133909 cites W2023895668 @default.
- W2014133909 cites W2030283142 @default.
- W2014133909 cites W2031727072 @default.
- W2014133909 cites W2032448671 @default.
- W2014133909 cites W2041108835 @default.
- W2014133909 cites W2050243029 @default.
- W2014133909 cites W2051214291 @default.
- W2014133909 cites W2052717817 @default.
- W2014133909 cites W2052728938 @default.
- W2014133909 cites W2071556591 @default.
- W2014133909 cites W2077237793 @default.
- W2014133909 cites W2081290278 @default.
- W2014133909 cites W2094115789 @default.
- W2014133909 cites W2101108802 @default.
- W2014133909 cites W2105599130 @default.
- W2014133909 cites W2108158680 @default.
- W2014133909 cites W2109327605 @default.
- W2014133909 cites W2114918609 @default.
- W2014133909 cites W2152854683 @default.
- W2014133909 cites W2403265245 @default.
- W2014133909 cites W4237865065 @default.
- W2014133909 cites W63697704 @default.
- W2014133909 cites W70621156 @default.
- W2014133909 doi "https://doi.org/10.1165/ajrcmb.17.6.2854" @default.
- W2014133909 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9409553" @default.
- W2014133909 hasPublicationYear "1997" @default.
- W2014133909 type Work @default.
- W2014133909 sameAs 2014133909 @default.
- W2014133909 citedByCount "41" @default.
- W2014133909 countsByYear W20141339092012 @default.
- W2014133909 countsByYear W20141339092013 @default.
- W2014133909 countsByYear W20141339092014 @default.
- W2014133909 countsByYear W20141339092016 @default.
- W2014133909 countsByYear W20141339092019 @default.
- W2014133909 countsByYear W20141339092020 @default.
- W2014133909 countsByYear W20141339092021 @default.
- W2014133909 crossrefType "journal-article" @default.
- W2014133909 hasAuthorship W2014133909A5002232142 @default.
- W2014133909 hasAuthorship W2014133909A5017502198 @default.
- W2014133909 hasAuthorship W2014133909A5017547671 @default.
- W2014133909 hasAuthorship W2014133909A5023904607 @default.
- W2014133909 hasAuthorship W2014133909A5050755009 @default.
- W2014133909 hasAuthorship W2014133909A5057592396 @default.
- W2014133909 hasAuthorship W2014133909A5062003491 @default.
- W2014133909 hasAuthorship W2014133909A5088709075 @default.
- W2014133909 hasConcept C105696609 @default.
- W2014133909 hasConcept C111963520 @default.
- W2014133909 hasConcept C134935766 @default.
- W2014133909 hasConcept C142724271 @default.
- W2014133909 hasConcept C143425029 @default.
- W2014133909 hasConcept C1491633281 @default.
- W2014133909 hasConcept C185592680 @default.
- W2014133909 hasConcept C190283241 @default.
- W2014133909 hasConcept C191897082 @default.
- W2014133909 hasConcept C192562407 @default.
- W2014133909 hasConcept C2909640154 @default.
- W2014133909 hasConcept C29537977 @default.
- W2014133909 hasConcept C510490043 @default.
- W2014133909 hasConcept C54355233 @default.
- W2014133909 hasConcept C552990157 @default.
- W2014133909 hasConcept C71924100 @default.
- W2014133909 hasConcept C85813293 @default.
- W2014133909 hasConcept C86803240 @default.
- W2014133909 hasConcept C93304396 @default.
- W2014133909 hasConcept C95444343 @default.
- W2014133909 hasConceptScore W2014133909C105696609 @default.
- W2014133909 hasConceptScore W2014133909C111963520 @default.
- W2014133909 hasConceptScore W2014133909C134935766 @default.
- W2014133909 hasConceptScore W2014133909C142724271 @default.
- W2014133909 hasConceptScore W2014133909C143425029 @default.
- W2014133909 hasConceptScore W2014133909C1491633281 @default.
- W2014133909 hasConceptScore W2014133909C185592680 @default.