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• W2014134483 abstract "In our study, luteolin has shown its apoptosis-inducing potent in HL-60 cells with its 76.5% apoptotic ratio of 100 μM treatment. When HL-60 cells were treated with 60 μM of luteolin, DNA ladders were visible at 6 h and increased from 6–12 h after treatment. Luteolin could decrease the mitochondrial membrane potential, trigger cytochrome c released to cytosol, and subsequently induce the processing of procaspase-9 and procaspase-3, which were followed by the cleavage of poly-(ADP-ribose) polymerase (PARP) and DNA fragmentation factor (DFF-45). The cleavage of the proapoptotic Bcl-2 proteins, such as Bad and Bax to produce their truncated forms, and the cleavage of the antiapoptotic Bcl-2 proteins, such as Bcl-2 and Bcl-XL, into their potent pro-apoptotic fragments were detected in our study. From the results, we suggested that the structure of luteolin contributes to its potent in inducing apoptosis in HL-60 cells, and the mitochondrial pathway might play an important role in the luteolin-induced apoptosis. The induction of apoptosis by luteolin may offer a pivotal mechanism for its cancertherapeutic and chemopreventive action." @default.
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• W2014134483 date "2005-02-01" @default.
• W2014134483 modified "2023-10-18" @default.
• W2014134483 title "Induction of apoptosis by luteolin through cleavage of Bcl-2 family in human leukemia HL-60 cells" @default.
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• W2014134483 doi "https://doi.org/10.1016/j.ejphar.2004.12.026" @default.
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