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- W2014137783 abstract "Dazoxiben, a thromboxane (Tx) synthesis inhibitor, was used in eight intact, mechanically ventilated, paralyzed cats to elucidate the role of Tx in the airway and vascular responses to the administration of A23187, a calcium ionophore, which releases arachidonic acid. Intravenous injections of A23187 produced dose-dependent increases in transpulmonary pressure and lung resistance and dose-dependent decreases in dynamic compliance and systemic arterial pressure. Airway responses to A23187 were reduced approximately 75% to 90% by dazoxiben. These changes in response to A23187 were significant at the p < 0.001 level for transpulmonary pressure and lung resistance and p < 0.05 for dynamic compliance. Decreases in arterial pressure in response to A23187 were not affected by dazoxiben. Airway responses to U-46619, a Tx A2 mimic, were maintained after dazoxiben blockade. Previous work in this laboratory showed blockade of responses to A23187 by SQ29,548, a thromboxane receptor antagonist, and meclofenamate, a cyclooxygenase inhibitor. The blockage suggests that airway responses to A23187 are mediated in large part by Tx A2. The current study extends our previous work on the mechanism of the airway effects of A23187. This study suggests that in the intact cat, the airway effects of A23187 are largely mediated by Tx A2, since they can be blocked by dazoxiben, a Tx synthesis inhibitor." @default.
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- W2014137783 date "1987-06-01" @default.
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- W2014137783 title "Inhibition of A23187-Induced Bronchoconstriction by Dazoxiben, a Thromboxane Synthetase Inhibitor" @default.
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- W2014137783 doi "https://doi.org/10.1097/00000441-198706000-00001" @default.
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