FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014139871> ?p ?o ?g. }

• W2014139871 endingPage "471" @default.
• W2014139871 startingPage "462" @default.
• W2014139871 abstract "Single-nucleotide polymorphisms (SNPs) are the most common source of genetic variation within a species; however, few investigations demonstrate how naturally occurring SNPs may increase strain virulence. We recently used group A Streptococcus as a model pathogen to study bacteria strain genotype-patient disease phenotype relationships. Whole-genome sequencing of approximately 800 serotype M59 group A Streptococcus strains, recovered during an outbreak of severe invasive infections across North America, identified a disproportionate number of SNPs in the gene encoding multiple gene regulator of group A Streptococcus (mga). Herein, we report results of studies designed to test the hypothesis that the most commonly occurring SNP, encoding a replacement of arginine for histidine at codon 201 of Mga (H201R), significantly increases virulence. Whole transcriptome analysis revealed that the H201R replacement significantly increased expression of mga and 54 other genes, including many proven virulence factors. Compared to the wild-type strain, a H201R isogenic mutant strain caused significantly larger skin lesions in mice. Serial quantitative bacterial culture and noninvasive magnetic resonance imaging also demonstrated that the isogenic H201R strain was significantly more virulent in a nonhuman primate model of joint infection. These findings show that the H201R replacement in Mga increases the virulence of M59 group A Streptococcus and provide new insight to how a naturally occurring SNP in bacteria contributes to human disease phenotypes." @default.
• W2014139871 created "2016-06-24" @default.
• W2014139871 creator A5010204053 @default.
• W2014139871 creator A5015229953 @default.
• W2014139871 creator A5022011099 @default.
• W2014139871 creator A5027390602 @default.
• W2014139871 creator A5027942646 @default.
• W2014139871 creator A5027989030 @default.
• W2014139871 creator A5032515537 @default.
• W2014139871 creator A5063848103 @default.
• W2014139871 creator A5068635066 @default.
• W2014139871 creator A5069200755 @default.
• W2014139871 creator A5082551216 @default.
• W2014139871 creator A5082755908 @default.
• W2014139871 creator A5083302825 @default.
• W2014139871 date "2015-02-01" @default.
• W2014139871 modified "2023-10-02" @default.
• W2014139871 title "A Naturally Occurring Single Amino Acid Replacement in Multiple Gene Regulator of Group A Streptococcus Significantly Increases Virulence" @default.
• W2014139871 cites W1593983986 @default.
• W2014139871 cites W1772393529 @default.
• W2014139871 cites W1843970506 @default.
• W2014139871 cites W1969022131 @default.
• W2014139871 cites W1969977416 @default.
• W2014139871 cites W1972801783 @default.
• W2014139871 cites W1983761774 @default.
• W2014139871 cites W1989769331 @default.
• W2014139871 cites W1993904162 @default.
• W2014139871 cites W1998384572 @default.
• W2014139871 cites W2002114667 @default.
• W2014139871 cites W2003265935 @default.
• W2014139871 cites W2017233895 @default.
• W2014139871 cites W2026935242 @default.
• W2014139871 cites W2026955495 @default.
• W2014139871 cites W2035824694 @default.
• W2014139871 cites W2036256066 @default.
• W2014139871 cites W2037409969 @default.
• W2014139871 cites W2044062601 @default.
• W2014139871 cites W2047550265 @default.
• W2014139871 cites W2051903478 @default.
• W2014139871 cites W2053949131 @default.
• W2014139871 cites W2054847015 @default.
• W2014139871 cites W2058656568 @default.
• W2014139871 cites W2073608837 @default.
• W2014139871 cites W2080207956 @default.
• W2014139871 cites W2080514113 @default.
• W2014139871 cites W2092425104 @default.
• W2014139871 cites W2098386825 @default.
• W2014139871 cites W2103458678 @default.
• W2014139871 cites W2110397854 @default.
• W2014139871 cites W2116757040 @default.
• W2014139871 cites W2116901163 @default.
• W2014139871 cites W2121782223 @default.
• W2014139871 cites W2130079166 @default.
• W2014139871 cites W2132565683 @default.
• W2014139871 cites W2132889718 @default.
• W2014139871 cites W2137678717 @default.
• W2014139871 cites W2137985139 @default.
• W2014139871 cites W2138968695 @default.
• W2014139871 cites W2140268200 @default.
• W2014139871 cites W2140385029 @default.
• W2014139871 cites W2147878474 @default.
• W2014139871 cites W2150986328 @default.
• W2014139871 cites W2154431984 @default.
• W2014139871 cites W2155201844 @default.
• W2014139871 cites W2157612734 @default.
• W2014139871 cites W2160645055 @default.
• W2014139871 cites W2163500752 @default.
• W2014139871 cites W2166527777 @default.
• W2014139871 cites W2168547182 @default.
• W2014139871 cites W2169171816 @default.
• W2014139871 cites W2169677384 @default.
• W2014139871 cites W2169958686 @default.
• W2014139871 cites W2301668719 @default.
• W2014139871 cites W2411071135 @default.
• W2014139871 doi "https://doi.org/10.1016/j.ajpath.2014.10.018" @default.
• W2014139871 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4305177" @default.
• W2014139871 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25476528" @default.
• W2014139871 hasPublicationYear "2015" @default.
• W2014139871 type Work @default.
• W2014139871 sameAs 2014139871 @default.
• W2014139871 citedByCount "18" @default.
• W2014139871 countsByYear W20141398712015 @default.
• W2014139871 countsByYear W20141398712016 @default.
• W2014139871 countsByYear W20141398712017 @default.
• W2014139871 countsByYear W20141398712018 @default.
• W2014139871 countsByYear W20141398712019 @default.
• W2014139871 countsByYear W20141398712020 @default.
• W2014139871 countsByYear W20141398712023 @default.
• W2014139871 crossrefType "journal-article" @default.
• W2014139871 hasAuthorship W2014139871A5010204053 @default.
• W2014139871 hasAuthorship W2014139871A5015229953 @default.
• W2014139871 hasAuthorship W2014139871A5022011099 @default.
• W2014139871 hasAuthorship W2014139871A5027390602 @default.
• W2014139871 hasAuthorship W2014139871A5027942646 @default.
• W2014139871 hasAuthorship W2014139871A5027989030 @default.
• W2014139871 hasAuthorship W2014139871A5032515537 @default.
• W2014139871 hasAuthorship W2014139871A5063848103 @default.
• W2014139871 hasAuthorship W2014139871A5068635066 @default.

• next