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- W2014142947 abstract "Abstract Type 2 diabetes is characterized by insulin resistance and β-cell dysfunction. The pathway of acylation-stimulating protein (ASP) and its specific receptor, C5a-like receptor 2 (C5L2), involves in the effective clearance of plasma glucose and free fat acid. Abnormal ASP-C5L2 pathway may induce insulin resistance, as well as cause hyperglycemia and elevated plasma free fat acid. High levels of plasma glucose and free fat acid induce β-cell apoptosis and dysfunction. We proposed that the abnormality of ASP-C5L2 pathway contributes to progression of type 2 diabetes." @default.
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- W2014142947 date "2009-01-01" @default.
- W2014142947 modified "2023-09-22" @default.
- W2014142947 title "The progression of type 2 diabetes: Partly caused by deficiency of ASP-C5L2 pathway?" @default.
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- W2014142947 doi "https://doi.org/10.1016/j.bihy.2009.05.003" @default.
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