FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014144028> ?p ?o ?g. }

• W2014144028 endingPage "909" @default.
• W2014144028 startingPage "903" @default.
• W2014144028 abstract "Ischemic postconditioning has been demonstrated to limit infarct size in patients, but its molecular mechanisms remain incompletely understood. Low intracellular pH (pHi) inhibits mitochondrial permeability transition, calpain activation and hypercontracture. Recently, delayed normalization of pHi during reperfusion has been shown to play an important role in postconditioning protection, but its relation with intracellular protective signaling cascades is unknown. The present study investigates the relation between the rate of pHi normalization and the cGMP/PKG pathway in postconditioned myocardium. In isolated Sprague–Dawley rat hearts submitted to transient ischemia both, postconditioning and acidic reperfusion protocols resulted in a similar delay in pHi recovery measured by 31P-NMR spectroscopy (3.6±0.2 min and 3.5±0.2 min respectively vs. 1.4±0.2 min in control group, P<0.01) and caused equivalent cardioprotection (48% and 41% of infarct reduction respectively, P<0.01), but only postconditioning increased myocardial cGMP levels (P=0.02) and activated PKG. Blockade of cGMP/PKG pathway by the addition of the guanylyl cyclase inhibitor ODQ or the PKG inhibitor KT5823 during reperfusion accelerated pHi recovery and abolished cardioprotection in postconditioned hearts, but had no effect in hearts subjected to acidic reperfusion suggesting that PKG signaling was upstream of delayed pHi normalization in postconditioned hearts. In isolated cardiomyocytes the cGMP analog 8-pCPT-cGMP delayed Na+/H+-exchange mediated pHi normalization after acidification induced by a NH4Cl pulse. These results demonstrate that the cGMP/PKG pathway contributes to postconditioning protection at least in part by delaying normalization of pHi during reperfusion, probably via PKG-dependent inhibition of Na+/H+-exchanger." @default.
• W2014144028 created "2016-06-24" @default.
• W2014144028 creator A5006099883 @default.
• W2014144028 creator A5012713403 @default.
• W2014144028 creator A5021962165 @default.
• W2014144028 creator A5024998324 @default.
• W2014144028 creator A5029887131 @default.
• W2014144028 creator A5049461964 @default.
• W2014144028 creator A5071713948 @default.
• W2014144028 date "2011-05-01" @default.
• W2014144028 modified "2023-10-17" @default.
• W2014144028 title "cGMP/PKG pathway mediates myocardial postconditioning protection in rat hearts by delaying normalization of intracellular acidosis during reperfusion" @default.
• W2014144028 cites W1965602603 @default.
• W2014144028 cites W1979026148 @default.
• W2014144028 cites W1985760529 @default.
• W2014144028 cites W1990994255 @default.
• W2014144028 cites W1991627669 @default.
• W2014144028 cites W1999637274 @default.
• W2014144028 cites W2000199293 @default.
• W2014144028 cites W2002211489 @default.
• W2014144028 cites W2021733224 @default.
• W2014144028 cites W2023036252 @default.
• W2014144028 cites W2023684729 @default.
• W2014144028 cites W2025155186 @default.
• W2014144028 cites W2026493851 @default.
• W2014144028 cites W2026977120 @default.
• W2014144028 cites W2049460661 @default.
• W2014144028 cites W2051533145 @default.
• W2014144028 cites W2053056001 @default.
• W2014144028 cites W2053135322 @default.
• W2014144028 cites W2065736920 @default.
• W2014144028 cites W2081787098 @default.
• W2014144028 cites W2082329828 @default.
• W2014144028 cites W2087126389 @default.
• W2014144028 cites W2092914889 @default.
• W2014144028 cites W2094895722 @default.
• W2014144028 cites W2103304753 @default.
• W2014144028 cites W2103918111 @default.
• W2014144028 cites W2122179672 @default.
• W2014144028 cites W2122974654 @default.
• W2014144028 cites W2128756478 @default.
• W2014144028 cites W2129483036 @default.
• W2014144028 cites W2131015734 @default.
• W2014144028 cites W2146386578 @default.
• W2014144028 cites W2152569187 @default.
• W2014144028 cites W2153298328 @default.
• W2014144028 cites W2154599586 @default.
• W2014144028 cites W2159606290 @default.
• W2014144028 cites W2164334501 @default.
• W2014144028 cites W2165637629 @default.
• W2014144028 cites W2170783132 @default.
• W2014144028 cites W2335277255 @default.
• W2014144028 doi "https://doi.org/10.1016/j.yjmcc.2011.02.013" @default.
• W2014144028 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21362429" @default.
• W2014144028 hasPublicationYear "2011" @default.
• W2014144028 type Work @default.
• W2014144028 sameAs 2014144028 @default.
• W2014144028 citedByCount "61" @default.
• W2014144028 countsByYear W20141440282012 @default.
• W2014144028 countsByYear W20141440282013 @default.
• W2014144028 countsByYear W20141440282014 @default.
• W2014144028 countsByYear W20141440282015 @default.
• W2014144028 countsByYear W20141440282016 @default.
• W2014144028 countsByYear W20141440282017 @default.
• W2014144028 countsByYear W20141440282018 @default.
• W2014144028 countsByYear W20141440282019 @default.
• W2014144028 countsByYear W20141440282020 @default.
• W2014144028 countsByYear W20141440282021 @default.
• W2014144028 countsByYear W20141440282022 @default.
• W2014144028 countsByYear W20141440282023 @default.
• W2014144028 crossrefType "journal-article" @default.
• W2014144028 hasAuthorship W2014144028A5006099883 @default.
• W2014144028 hasAuthorship W2014144028A5012713403 @default.
• W2014144028 hasAuthorship W2014144028A5021962165 @default.
• W2014144028 hasAuthorship W2014144028A5024998324 @default.
• W2014144028 hasAuthorship W2014144028A5029887131 @default.
• W2014144028 hasAuthorship W2014144028A5049461964 @default.
• W2014144028 hasAuthorship W2014144028A5071713948 @default.
• W2014144028 hasConcept C126322002 @default.
• W2014144028 hasConcept C13591479 @default.
• W2014144028 hasConcept C164705383 @default.
• W2014144028 hasConcept C173803235 @default.
• W2014144028 hasConcept C185592680 @default.
• W2014144028 hasConcept C190283241 @default.
• W2014144028 hasConcept C195794163 @default.
• W2014144028 hasConcept C199217515 @default.
• W2014144028 hasConcept C2778827303 @default.
• W2014144028 hasConcept C2779676291 @default.
• W2014144028 hasConcept C2780114680 @default.
• W2014144028 hasConcept C31573885 @default.
• W2014144028 hasConcept C519581460 @default.
• W2014144028 hasConcept C541997718 @default.
• W2014144028 hasConcept C55493867 @default.
• W2014144028 hasConcept C62478195 @default.
• W2014144028 hasConcept C71924100 @default.
• W2014144028 hasConcept C79879829 @default.
• W2014144028 hasConcept C90934575 @default.
• W2014144028 hasConcept C98274493 @default.

• next