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- W2014144626 abstract "Vein thrombosis is often encountered in microsurgery, especially in the case of crush-avulsion injuries. The aim of this study was to investigate the effect of systemic administration of recombinant tissue-type plasminogen activator (rt-PA) on the patency of the femoral vein of the rat, which had previously sustained a crush-avulsion injury. The study consisted of 3 groups of male Wistar rats, 20 animals each. A standardized crush-avulsion injury model was used. After microvascular repair of the femoral vein, the animals received either normal saline (group A), heparin 100 U/kg body weight (group B), or rt-PA 3.5 mg/kg body weight (group C) systemically. Patency tests were performed at 20 minutes, 48 hours, and 1 week after blood flow reestablishment. According to our results, the patency rate of the rt-PA group was significantly higher than in both the control and heparin groups." @default.
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- W2014144626 date "2001-01-01" @default.
- W2014144626 modified "2023-09-27" @default.
- W2014144626 title "Microsurgical repair after crush-avulsion injury of the femoral vein in rats: Prevention of microvascular thrombosis with recombinant human tissue-type plasminogen activator (rt-PA)" @default.
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- W2014144626 doi "https://doi.org/10.1002/micr.21808" @default.
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