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• W2014147848 abstract "anergy induction for CD63 upregulation has the same characteristics reported for the suppression of histamine secretion CD203c is upregulated independently of CD63 and could be useful as a marker for desensitization Basophil anergy is pathway, but not antigen specific hydrogen peroxide is produced by oxidative burst in basophils and it can modulate the response to IgE-mediated activation hydrogen peroxide augments the phosphorylation of Syk, Btk, Erk by IgE cross-linking degranulation, however, is suppressed (as is 203 upregulation) – thought to be via PTPs (orthovanadate also has this effect). A distinct pathway for Erk phosphorylation is activated, and those cells are anergized for IgE, but not fMLP stim while peroxide effect is thought to be secondary to PTPs, neither lyn, nor syk are activated Word Count = 1701" @default.
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• W2014147848 date "2010-02-01" @default.
• W2014147848 modified "2023-09-25" @default.
• W2014147848 title "Protein Tyrosine Phosphatase Inhibition Mimics FcεRI-Induced Anergy and Reveals the Immunomodulatory Role of Hydrogen Peroxide as a Signaling Molecule in Human Basophils" @default.
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• W2014147848 doi "https://doi.org/10.1016/j.jaci.2009.12.928" @default.
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