Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014148833> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2014148833 endingPage "532" @default.
- W2014148833 startingPage "528" @default.
- W2014148833 abstract "Insulin secretion is stimulated by glucose, hormones and neurotransmitters. Both activation of a non-selective cation current and activation of a Ca2+ current in response to depletion of intracellular Ca2+ stores have been suggested to play a role in this stimulation. The properties of these currents resemble those reported for the Drosophila genes trp and trpl. Using the reverse transcription polymerase chain reaction and Northern blot analysis we found that of the six mammalian trp-related genes (trp1-6), only trp1 was expressed at high levels in the mouse insulinoma cell line MIN6. We cloned the murine homologue of human trp1 from MIN6 cells and identified four variants (alpha, beta, gamma and delta), generated by alternative splicing near the N-terminus of the protein. In vitro translation showed that only the alpha and beta splice variants are efficiently expressed. The beta variant is the dominant form in MIN6 cells (and probably in mouse pancreatic islets), whereas the alpha variant is the major type in the mouse brain. The beta variant showed 99% identity to the human homologue at the amino acid level." @default.
- W2014148833 created "2016-06-24" @default.
- W2014148833 creator A5007175284 @default.
- W2014148833 creator A5057273983 @default.
- W2014148833 date "1997-04-24" @default.
- W2014148833 modified "2023-10-18" @default.
- W2014148833 title "Identification of four trp 1 gene variants murine pancreatic beta-cells" @default.
- W2014148833 cites W1647773117 @default.
- W2014148833 cites W1846475715 @default.
- W2014148833 cites W1859293501 @default.
- W2014148833 cites W1874327812 @default.
- W2014148833 cites W1971473766 @default.
- W2014148833 cites W1975742198 @default.
- W2014148833 cites W1983933954 @default.
- W2014148833 cites W1992045485 @default.
- W2014148833 cites W2004855020 @default.
- W2014148833 cites W2050342883 @default.
- W2014148833 cites W2059883534 @default.
- W2014148833 cites W2066556958 @default.
- W2014148833 cites W2067704395 @default.
- W2014148833 cites W2070042249 @default.
- W2014148833 cites W2076969616 @default.
- W2014148833 cites W2093661120 @default.
- W2014148833 doi "https://doi.org/10.1007/s001250050711" @default.
- W2014148833 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9165220" @default.
- W2014148833 hasPublicationYear "1997" @default.
- W2014148833 type Work @default.
- W2014148833 sameAs 2014148833 @default.
- W2014148833 citedByCount "87" @default.
- W2014148833 countsByYear W20141488332012 @default.
- W2014148833 countsByYear W20141488332013 @default.
- W2014148833 countsByYear W20141488332014 @default.
- W2014148833 countsByYear W20141488332015 @default.
- W2014148833 countsByYear W20141488332016 @default.
- W2014148833 countsByYear W20141488332017 @default.
- W2014148833 countsByYear W20141488332019 @default.
- W2014148833 countsByYear W20141488332020 @default.
- W2014148833 countsByYear W20141488332021 @default.
- W2014148833 crossrefType "journal-article" @default.
- W2014148833 hasAuthorship W2014148833A5007175284 @default.
- W2014148833 hasAuthorship W2014148833A5057273983 @default.
- W2014148833 hasBestOaLocation W20141488331 @default.
- W2014148833 hasConcept C104317684 @default.
- W2014148833 hasConcept C134018914 @default.
- W2014148833 hasConcept C153911025 @default.
- W2014148833 hasConcept C165220095 @default.
- W2014148833 hasConcept C194583182 @default.
- W2014148833 hasConcept C199360897 @default.
- W2014148833 hasConcept C2776174256 @default.
- W2014148833 hasConcept C2776828364 @default.
- W2014148833 hasConcept C2778764654 @default.
- W2014148833 hasConcept C2779306644 @default.
- W2014148833 hasConcept C2779855799 @default.
- W2014148833 hasConcept C2780053029 @default.
- W2014148833 hasConcept C36823959 @default.
- W2014148833 hasConcept C41008148 @default.
- W2014148833 hasConcept C54458228 @default.
- W2014148833 hasConcept C55493867 @default.
- W2014148833 hasConcept C67705224 @default.
- W2014148833 hasConcept C86803240 @default.
- W2014148833 hasConceptScore W2014148833C104317684 @default.
- W2014148833 hasConceptScore W2014148833C134018914 @default.
- W2014148833 hasConceptScore W2014148833C153911025 @default.
- W2014148833 hasConceptScore W2014148833C165220095 @default.
- W2014148833 hasConceptScore W2014148833C194583182 @default.
- W2014148833 hasConceptScore W2014148833C199360897 @default.
- W2014148833 hasConceptScore W2014148833C2776174256 @default.
- W2014148833 hasConceptScore W2014148833C2776828364 @default.
- W2014148833 hasConceptScore W2014148833C2778764654 @default.
- W2014148833 hasConceptScore W2014148833C2779306644 @default.
- W2014148833 hasConceptScore W2014148833C2779855799 @default.
- W2014148833 hasConceptScore W2014148833C2780053029 @default.
- W2014148833 hasConceptScore W2014148833C36823959 @default.
- W2014148833 hasConceptScore W2014148833C41008148 @default.
- W2014148833 hasConceptScore W2014148833C54458228 @default.
- W2014148833 hasConceptScore W2014148833C55493867 @default.
- W2014148833 hasConceptScore W2014148833C67705224 @default.
- W2014148833 hasConceptScore W2014148833C86803240 @default.
- W2014148833 hasIssue "5" @default.
- W2014148833 hasLocation W20141488331 @default.
- W2014148833 hasLocation W20141488332 @default.
- W2014148833 hasOpenAccess W2014148833 @default.
- W2014148833 hasPrimaryLocation W20141488331 @default.
- W2014148833 hasRelatedWork W1976843764 @default.
- W2014148833 hasRelatedWork W2022596900 @default.
- W2014148833 hasRelatedWork W2053656597 @default.
- W2014148833 hasRelatedWork W2112189313 @default.
- W2014148833 hasRelatedWork W2139592023 @default.
- W2014148833 hasRelatedWork W2151954452 @default.
- W2014148833 hasRelatedWork W2520430930 @default.
- W2014148833 hasRelatedWork W2564462691 @default.
- W2014148833 hasRelatedWork W3200077090 @default.
- W2014148833 hasRelatedWork W4246630639 @default.
- W2014148833 hasVolume "40" @default.
- W2014148833 isParatext "false" @default.
- W2014148833 isRetracted "false" @default.
- W2014148833 magId "2014148833" @default.
- W2014148833 workType "article" @default.