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- W2014154109 abstract "Mast cell tumors (MCTs) are the most common tumors in dogs, accounting for 16–21% of cutaneous tumors. Although several small molecule inhibitors, including imatinib mesylate, have been used for the treatment of MCTs, the response rate remains less than 50%. In this study, the effects of different selective signal inhibitors on MCT cell growth were evaluated using 4 different cell lines derived from dogs. We found that the phosphoinositide 3-kinase (PI3K) signaling pathway is crucial for the proliferation of MCT cells in the presence or absence of c-kit gene mutations. Here, we propose a novel therapeutic strategy to target the PI3K pathway for the treatment of canine MCTs." @default.
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- W2014154109 date "2013-01-01" @default.
- W2014154109 modified "2023-10-07" @default.
- W2014154109 title "The Phosphoinositide 3-Kinase Pathway Is Crucial for the Growth of Canine Mast Cell Tumors" @default.
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- W2014154109 doi "https://doi.org/10.1292/jvms.12-0540" @default.
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