Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014156502> ?p ?o ?g. }
- W2014156502 endingPage "924" @default.
- W2014156502 startingPage "909" @default.
- W2014156502 abstract "We discuss the potential use of inhibitors of Kv1.3 potassium channels in T lymphocytes as therapeutics for multiple sclerosis. Current treatment strategies target the immune system in a non-selective manner. The resulting general immunosuppression, toxic side-effects and increased risk of opportunistic infections create the need for more selective therapeutics. Autoreactive effector-memory T (TEM) cells, considered to be major mediators of autoimmunity, express large numbers of Kv1.3 channels. Selective blockers of Kv1.3 inhibit calcium signaling, cytokine production and proliferation of TEM cells in vitro, and TEM cell-motility in vivo. Kv1.3 blockers ameliorate disease in animal models of multiple sclerosis, rheumatoid arthritis, type 1 diabetes mellitus and contact dermatitis without compromising the protective immune response to acute infections. Kv1.3 blockers have a good safety profile in rodents and primates." @default.
- W2014156502 created "2016-06-24" @default.
- W2014156502 creator A5014749047 @default.
- W2014156502 creator A5017569912 @default.
- W2014156502 creator A5043567383 @default.
- W2014156502 creator A5079484361 @default.
- W2014156502 date "2009-06-20" @default.
- W2014156502 modified "2023-10-18" @default.
- W2014156502 title "Kv1.3 potassium channels as a therapeutic target in multiple sclerosis" @default.
- W2014156502 cites W1492213776 @default.
- W2014156502 cites W1503182769 @default.
- W2014156502 cites W1596982521 @default.
- W2014156502 cites W1603793449 @default.
- W2014156502 cites W1680442092 @default.
- W2014156502 cites W1724878157 @default.
- W2014156502 cites W1843679466 @default.
- W2014156502 cites W1910853730 @default.
- W2014156502 cites W1936888634 @default.
- W2014156502 cites W1964258914 @default.
- W2014156502 cites W1965304178 @default.
- W2014156502 cites W1966137955 @default.
- W2014156502 cites W1966784203 @default.
- W2014156502 cites W1968403718 @default.
- W2014156502 cites W1972442533 @default.
- W2014156502 cites W1973670013 @default.
- W2014156502 cites W1974095902 @default.
- W2014156502 cites W1975605058 @default.
- W2014156502 cites W1976077967 @default.
- W2014156502 cites W1978017640 @default.
- W2014156502 cites W1978979524 @default.
- W2014156502 cites W1979573280 @default.
- W2014156502 cites W1979915354 @default.
- W2014156502 cites W1982054297 @default.
- W2014156502 cites W1983443399 @default.
- W2014156502 cites W1984007962 @default.
- W2014156502 cites W1984445978 @default.
- W2014156502 cites W1991941454 @default.
- W2014156502 cites W1993298907 @default.
- W2014156502 cites W1994995252 @default.
- W2014156502 cites W1995380719 @default.
- W2014156502 cites W1996787636 @default.
- W2014156502 cites W1997006403 @default.
- W2014156502 cites W2001917660 @default.
- W2014156502 cites W2003197155 @default.
- W2014156502 cites W2004947583 @default.
- W2014156502 cites W2006715289 @default.
- W2014156502 cites W2006715336 @default.
- W2014156502 cites W2008547188 @default.
- W2014156502 cites W2012462160 @default.
- W2014156502 cites W2012650768 @default.
- W2014156502 cites W2012801243 @default.
- W2014156502 cites W2013152019 @default.
- W2014156502 cites W2014229458 @default.
- W2014156502 cites W2017610520 @default.
- W2014156502 cites W2019023589 @default.
- W2014156502 cites W2019279189 @default.
- W2014156502 cites W2019310318 @default.
- W2014156502 cites W2019947683 @default.
- W2014156502 cites W2020311023 @default.
- W2014156502 cites W2020477012 @default.
- W2014156502 cites W2020708758 @default.
- W2014156502 cites W2021547033 @default.
- W2014156502 cites W2021843758 @default.
- W2014156502 cites W2022760884 @default.
- W2014156502 cites W2026708997 @default.
- W2014156502 cites W2028077169 @default.
- W2014156502 cites W2033818790 @default.
- W2014156502 cites W2033877575 @default.
- W2014156502 cites W2034245104 @default.
- W2014156502 cites W2036209063 @default.
- W2014156502 cites W2036472833 @default.
- W2014156502 cites W2036704251 @default.
- W2014156502 cites W2037539407 @default.
- W2014156502 cites W2037959104 @default.
- W2014156502 cites W2045281561 @default.
- W2014156502 cites W2050407053 @default.
- W2014156502 cites W2050970967 @default.
- W2014156502 cites W2051040059 @default.
- W2014156502 cites W2052124270 @default.
- W2014156502 cites W2052440750 @default.
- W2014156502 cites W2052531952 @default.
- W2014156502 cites W2053546226 @default.
- W2014156502 cites W2056075690 @default.
- W2014156502 cites W2057629693 @default.
- W2014156502 cites W2059321525 @default.
- W2014156502 cites W2060201104 @default.
- W2014156502 cites W2061519511 @default.
- W2014156502 cites W2063781776 @default.
- W2014156502 cites W2066283173 @default.
- W2014156502 cites W2067249361 @default.
- W2014156502 cites W2068640696 @default.
- W2014156502 cites W2071270895 @default.
- W2014156502 cites W2077248910 @default.
- W2014156502 cites W2078894239 @default.
- W2014156502 cites W2079603833 @default.
- W2014156502 cites W2084071646 @default.
- W2014156502 cites W2084357452 @default.
- W2014156502 cites W2086256855 @default.