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• W2014156610 abstract "BACKGROUND: Colorectal cancer (CRC) is the second most frequent cancer and the second cause of mortality related to cancer in Argentina. The detection of premalignant lesions (PML) through colonoscopy has been demonstrated to be effective in the prevention of CRC. It is important to be aware of the prevalence of these lesions to estimate their impact on the prevention of CRC in our population. The aim of this study was to assess the prevalence of PML in asymptomatic subjects with different levels of risk of CRC. METHODS: A cross-sectional analysis was performed based on the colonoscopy records of asymptomatic subjects screened for CRC in a General Hospital of Buenos Aires City, Argentina, between July 2004 and March 2007. The prevalence of PML was assessed in 2 groups: 1) average risk and 2) first-degree relatives with CRC. Patients with incomplete colonoscopy, poor preparation or second-degree relatives with CRCwere excluded. PMLwas defined as polyps or flat adenomaswith low or high-grade dysplasia.Multivariate logistic analysis was performed to establish the association between individual characteristics and PML. RESULTS: Data from 1233 subjects was collected (female= 733, mean age= 67.6 years SD= ±11.2). We found a global prevalence of 24.1% for PML and 1.1% for CRC. Average risk group (n=476; female= 246; mean age=61.8 years SD= ±9,06) showed a prevalence of 22.1% for PML (CI 95%= 18.3-25.8), in which 19.2% had low-grade and 2.5% high-grade dysplasia. The prevalence of CRC was 1.05%. First-degree relatives group (n=757; female =487; mean age= 54.9 years SD= ±11.53) showed a prevalence of 25.2% (CI 95%=22.1-28.3), in which 20% had lowgrade and 4.8% high-grade dysplasia. The prevalence of CRC in this group was 1.2%. In the validation set a logistic regressionmodel showed that family history of CRCwas independently associated with increased risk of PML (odds ratio=1.54; CI 95%= 1.15-2.05; P=0.004). This difference was greater in younger subjects (table 1). Male sex was also independently associated with an increased risk of PML (odds ratio=1.50; IC 95%= 1.15-1.97; P=0.003). CONCLUSION: Approximately a quarter of this population presented at least one PML and a significantly increased risk in first-degree relatives with CRC and male sex was observed. These results may contribute to issue local guidelines for CRC prevention. Table 1. Prevalence in different age groups" @default.
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• W2014156610 date "2008-04-01" @default.
• W2014156610 modified "2023-09-27" @default.
• W2014156610 title "S1022 Prevalence of Colorectal Premalignant Lesions Detected By Colonoscopy in Different Risk Groups for Colorectar Cancer" @default.
• W2014156610 doi "https://doi.org/10.1016/s0016-5085(08)60746-5" @default.
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