FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014162525> ?p ?o ?g. }

• W2014162525 endingPage "94" @default.
• W2014162525 startingPage "83" @default.
• W2014162525 abstract "Many pairs of genes in Escherichia coli are driven by closely spaced promoters. We study the dynamics of expression of such pairs of genes driven by a model at the molecule and nucleotide level with delayed stochastic dynamics as a function of the binding affinity of the RNA polymerase to the promoter region, of the geometry of the promoter, of the distance between transcription start sites (TSSs) and of the repression mechanism. We find that the rate limiting steps of transcription at the TSS, the closed and open complex formations, strongly affect the kinetics of RNA production for all promoter configurations. Beyond a certain rate of transcription initiation events, we find that the interference between polymerases correlates the dynamics of production of the two RNA molecules from the two TSS and affects the distribution of intervals between consecutive productions of RNA molecules. The degree of correlation depends on the geometry, the distance between TSSs and repressors. Small changes in the distance between TSSs can cause abrupt changes in behavior patterns, suggesting that the sequence between adjacent promoters may be subject to strong selective pressure. The results provide better understanding on the sequence level mechanisms of transcription regulation in bacteria and may aid in the genetic engineering of artificial circuits based on closely spaced promoters." @default.
• W2014162525 created "2016-06-24" @default.
• W2014162525 creator A5010179430 @default.
• W2014162525 creator A5026230936 @default.
• W2014162525 creator A5027206228 @default.
• W2014162525 creator A5033673376 @default.
• W2014162525 creator A5034858108 @default.
• W2014162525 creator A5040628945 @default.
• W2014162525 creator A5059431218 @default.
• W2014162525 date "2012-05-01" @default.
• W2014162525 modified "2023-09-26" @default.
• W2014162525 title "Dynamics of transcription of closely spaced promoters in Escherichia coli, one event at a time" @default.
• W2014162525 cites W1495265719 @default.
• W2014162525 cites W1595426874 @default.
• W2014162525 cites W1608763722 @default.
• W2014162525 cites W1645305843 @default.
• W2014162525 cites W1790898293 @default.
• W2014162525 cites W1946177469 @default.
• W2014162525 cites W1970625978 @default.
• W2014162525 cites W1975232273 @default.
• W2014162525 cites W1978723962 @default.
• W2014162525 cites W1980695770 @default.
• W2014162525 cites W1982396530 @default.
• W2014162525 cites W1984618686 @default.
• W2014162525 cites W1984916226 @default.
• W2014162525 cites W1995277107 @default.
• W2014162525 cites W1996691828 @default.
• W2014162525 cites W2001394772 @default.
• W2014162525 cites W2003931365 @default.
• W2014162525 cites W2008507782 @default.
• W2014162525 cites W2009217296 @default.
• W2014162525 cites W2011097028 @default.
• W2014162525 cites W2019196439 @default.
• W2014162525 cites W2019472515 @default.
• W2014162525 cites W2019685233 @default.
• W2014162525 cites W2027723603 @default.
• W2014162525 cites W2035987806 @default.
• W2014162525 cites W2038539945 @default.
• W2014162525 cites W2049222491 @default.
• W2014162525 cites W2052094781 @default.
• W2014162525 cites W2053460598 @default.
• W2014162525 cites W2054331129 @default.
• W2014162525 cites W2056573287 @default.
• W2014162525 cites W2078771267 @default.
• W2014162525 cites W2081567538 @default.
• W2014162525 cites W2082148398 @default.
• W2014162525 cites W2105466636 @default.
• W2014162525 cites W2114625694 @default.
• W2014162525 cites W2122879816 @default.
• W2014162525 cites W2134440848 @default.
• W2014162525 cites W2134759932 @default.
• W2014162525 cites W2135054636 @default.
• W2014162525 cites W2137112190 @default.
• W2014162525 cites W2140158396 @default.
• W2014162525 cites W2145246556 @default.
• W2014162525 cites W2155163956 @default.
• W2014162525 cites W2155418451 @default.
• W2014162525 cites W2164536093 @default.
• W2014162525 cites W2167244112 @default.
• W2014162525 doi "https://doi.org/10.1016/j.jtbi.2012.02.015" @default.
• W2014162525 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22370562" @default.
• W2014162525 hasPublicationYear "2012" @default.
• W2014162525 type Work @default.
• W2014162525 sameAs 2014162525 @default.
• W2014162525 citedByCount "5" @default.
• W2014162525 countsByYear W20141625252013 @default.
• W2014162525 countsByYear W20141625252016 @default.
• W2014162525 countsByYear W20141625252019 @default.
• W2014162525 countsByYear W20141625252021 @default.
• W2014162525 countsByYear W20141625252022 @default.
• W2014162525 crossrefType "journal-article" @default.
• W2014162525 hasAuthorship W2014162525A5010179430 @default.
• W2014162525 hasAuthorship W2014162525A5026230936 @default.
• W2014162525 hasAuthorship W2014162525A5027206228 @default.
• W2014162525 hasAuthorship W2014162525A5033673376 @default.
• W2014162525 hasAuthorship W2014162525A5034858108 @default.
• W2014162525 hasAuthorship W2014162525A5040628945 @default.
• W2014162525 hasAuthorship W2014162525A5059431218 @default.
• W2014162525 hasConcept C101762097 @default.
• W2014162525 hasConcept C104317684 @default.
• W2014162525 hasConcept C138885662 @default.
• W2014162525 hasConcept C150194340 @default.
• W2014162525 hasConcept C158448853 @default.
• W2014162525 hasConcept C179926584 @default.
• W2014162525 hasConcept C186310378 @default.
• W2014162525 hasConcept C2776449523 @default.
• W2014162525 hasConcept C41895202 @default.
• W2014162525 hasConcept C54355233 @default.
• W2014162525 hasConcept C67705224 @default.
• W2014162525 hasConcept C86803240 @default.
• W2014162525 hasConceptScore W2014162525C101762097 @default.
• W2014162525 hasConceptScore W2014162525C104317684 @default.
• W2014162525 hasConceptScore W2014162525C138885662 @default.
• W2014162525 hasConceptScore W2014162525C150194340 @default.
• W2014162525 hasConceptScore W2014162525C158448853 @default.
• W2014162525 hasConceptScore W2014162525C179926584 @default.
• W2014162525 hasConceptScore W2014162525C186310378 @default.
• W2014162525 hasConceptScore W2014162525C2776449523 @default.

• next