Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014162629> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W2014162629 endingPage "11" @default.
- W2014162629 startingPage "1" @default.
- W2014162629 abstract "Three methods, equilibrium dialysis, ultrafiltration through dialysis bags, and ultrafiltration through ultrafree filters were compared for the determination of propranolol binding in serum. The method of choice was equilibrium dialysis, which gave values for the free fraction which were not significantly different from those obtained by ultrafiltration through the filters. Of the three methods, equilibrium dialysis also had the best precision and required the least sample volume (1 ml). Similar values for the free fraction were also obtained using either 14C- or 3H-radiolabeled propranolol by this method. Investigation of the effect of temperature and pH of serum indicated that small changes in either parameter could result in up to twofold alterations in the free fraction, but changes in propranolol concentrations over the range 10-500 ng/ml had little effect on the free fraction. Using a standardized equilibrium dialysis method (i.e., 4 hr dialysis against isotonic phosphate buffer, at 37 degrees C, pH 7.4), a mean free fraction of 14.7% (range 8.4-23.3) was observed in 34 samples from 21 healthy subjects. This was significantly greater (p less than 0.001) than that (6.8%, range 3.1-12.3) found in nine elderly hospitalized patients with acute disease. The patients also had significantly raised levels of alpha 1-acid glycoprotein (AAG), which is a major binding protein for propranolol in serum. A significant linear correlation (r = 0.884, p less than 0.02) was found between the binding ratio for propranolol and serum AAG concentrations in these subjects." @default.
- W2014162629 created "2016-06-24" @default.
- W2014162629 creator A5042349110 @default.
- W2014162629 creator A5056011943 @default.
- W2014162629 date "1983-08-01" @default.
- W2014162629 modified "2023-10-16" @default.
- W2014162629 title "Propranolol binding in serum: Comparison of methods and investigation of effects of Drug Concentration, pH, and temperature" @default.
- W2014162629 cites W119243411 @default.
- W2014162629 cites W1963537472 @default.
- W2014162629 cites W1972822049 @default.
- W2014162629 cites W1975579934 @default.
- W2014162629 cites W1977585659 @default.
- W2014162629 cites W1980685532 @default.
- W2014162629 cites W1980903735 @default.
- W2014162629 cites W1983920076 @default.
- W2014162629 cites W1984229786 @default.
- W2014162629 cites W1988200797 @default.
- W2014162629 cites W1988776154 @default.
- W2014162629 cites W1999674243 @default.
- W2014162629 cites W2006506059 @default.
- W2014162629 cites W2017902123 @default.
- W2014162629 cites W2022899608 @default.
- W2014162629 cites W2032877182 @default.
- W2014162629 cites W2039304356 @default.
- W2014162629 cites W2052427240 @default.
- W2014162629 cites W2062011100 @default.
- W2014162629 cites W2062993780 @default.
- W2014162629 cites W2063359791 @default.
- W2014162629 cites W2079447692 @default.
- W2014162629 cites W2143312213 @default.
- W2014162629 cites W2233492637 @default.
- W2014162629 cites W2336516640 @default.
- W2014162629 cites W2339179533 @default.
- W2014162629 cites W2469907948 @default.
- W2014162629 doi "https://doi.org/10.1016/0160-5402(83)90009-8" @default.
- W2014162629 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6632919" @default.
- W2014162629 hasPublicationYear "1983" @default.
- W2014162629 type Work @default.
- W2014162629 sameAs 2014162629 @default.
- W2014162629 citedByCount "22" @default.
- W2014162629 countsByYear W20141626292012 @default.
- W2014162629 countsByYear W20141626292014 @default.
- W2014162629 countsByYear W20141626292017 @default.
- W2014162629 countsByYear W20141626292020 @default.
- W2014162629 countsByYear W20141626292022 @default.
- W2014162629 crossrefType "journal-article" @default.
- W2014162629 hasAuthorship W2014162629A5042349110 @default.
- W2014162629 hasAuthorship W2014162629A5056011943 @default.
- W2014162629 hasConcept C126322002 @default.
- W2014162629 hasConcept C185592680 @default.
- W2014162629 hasConcept C2778151854 @default.
- W2014162629 hasConcept C2779978075 @default.
- W2014162629 hasConcept C2781233306 @default.
- W2014162629 hasConcept C43617362 @default.
- W2014162629 hasConcept C50817676 @default.
- W2014162629 hasConcept C51639874 @default.
- W2014162629 hasConcept C55493867 @default.
- W2014162629 hasConcept C71924100 @default.
- W2014162629 hasConceptScore W2014162629C126322002 @default.
- W2014162629 hasConceptScore W2014162629C185592680 @default.
- W2014162629 hasConceptScore W2014162629C2778151854 @default.
- W2014162629 hasConceptScore W2014162629C2779978075 @default.
- W2014162629 hasConceptScore W2014162629C2781233306 @default.
- W2014162629 hasConceptScore W2014162629C43617362 @default.
- W2014162629 hasConceptScore W2014162629C50817676 @default.
- W2014162629 hasConceptScore W2014162629C51639874 @default.
- W2014162629 hasConceptScore W2014162629C55493867 @default.
- W2014162629 hasConceptScore W2014162629C71924100 @default.
- W2014162629 hasIssue "1" @default.
- W2014162629 hasLocation W20141626291 @default.
- W2014162629 hasLocation W20141626292 @default.
- W2014162629 hasOpenAccess W2014162629 @default.
- W2014162629 hasPrimaryLocation W20141626291 @default.
- W2014162629 hasRelatedWork W1820995864 @default.
- W2014162629 hasRelatedWork W1975418338 @default.
- W2014162629 hasRelatedWork W2007189280 @default.
- W2014162629 hasRelatedWork W2033469754 @default.
- W2014162629 hasRelatedWork W2052590236 @default.
- W2014162629 hasRelatedWork W2069842851 @default.
- W2014162629 hasRelatedWork W2083180751 @default.
- W2014162629 hasRelatedWork W2165909450 @default.
- W2014162629 hasRelatedWork W2412901737 @default.
- W2014162629 hasRelatedWork W3109597423 @default.
- W2014162629 hasVolume "10" @default.
- W2014162629 isParatext "false" @default.
- W2014162629 isRetracted "false" @default.
- W2014162629 magId "2014162629" @default.
- W2014162629 workType "article" @default.