FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014164087> ?p ?o ?g. }

• W2014164087 endingPage "282" @default.
• W2014164087 startingPage "275" @default.
• W2014164087 abstract "We investigated the hypericin-mediated PDT effects on the tumor and normal skin and in correlation with its biodistribution. These studies were carried out on C3H mice bearing RIF-1 tumors. The hypericin distribution and PDT effects were recorded at different intervals (0.5-24 hr) after intravenous injection of a 5-mg/kg dose of hypericin. After administration, rapid biphasic exponential decay was observed in the plasma drug concentration. It was found that hypericin was preferentially bound to the plasma lipoproteins. The tumor drug levels increased rapidly over the first few hours and reached a maximum around 6 hr after injection. In contrast, PDT efficacy was maximal when irradiation was performed at 0.5 hr after hypericin administration, which led to 100% cure. The PDT efficacy decreased rapidly as the administration-irradiation interval was prolonged. No tumor cure was obtained at the 6-hr interval, even though it was at this time that the tumor drug level peaked. Fluorescence microscopic studies showed that hypericin was mainly confined within the tumor vasculature at 0.5 hr after injection, whereupon it rapidly diffused to the surrounding tumor tissue. At 6 hr, a strong hypericin fluorescence was observed in the tumor tissue with only faint fluorescence within the vasculature, whereas at 24 hr the fluorescence in the tumor also decreased and became more diffused, and no fluorescence could be seen in the tumor vasculature. Like the tumor response, skin reactions were also found to be much more dramatic at short administration-irradiation intervals. Hypericin distribution and PDT response studies revealed a close correlation between the plasma drug level and the PDT effects, which suggests that vascular damage is the primary effect of hypericin-mediated PDT in this tumor model." @default.
• W2014164087 created "2016-06-24" @default.
• W2014164087 creator A5005835095 @default.
• W2014164087 creator A5008017292 @default.
• W2014164087 creator A5027622225 @default.
• W2014164087 creator A5035008429 @default.
• W2014164087 creator A5055843644 @default.
• W2014164087 creator A5067200658 @default.
• W2014164087 creator A5091862786 @default.
• W2014164087 date "2001-01-01" @default.
• W2014164087 modified "2023-10-12" @default.
• W2014164087 title "Efficacy of antitumoral photodynamic therapy with hypericin: Relationship between biodistribution and photodynamic effects in the RIF-1 mouse tumor model" @default.
• W2014164087 cites W159741139 @default.
• W2014164087 cites W1966176408 @default.
• W2014164087 cites W1966924017 @default.
• W2014164087 cites W1967106734 @default.
• W2014164087 cites W1978621328 @default.
• W2014164087 cites W1982978600 @default.
• W2014164087 cites W1998119038 @default.
• W2014164087 cites W1998168743 @default.
• W2014164087 cites W1998424046 @default.
• W2014164087 cites W2001212685 @default.
• W2014164087 cites W2007075465 @default.
• W2014164087 cites W2008536525 @default.
• W2014164087 cites W2011973907 @default.
• W2014164087 cites W2016905678 @default.
• W2014164087 cites W2018272990 @default.
• W2014164087 cites W2029942079 @default.
• W2014164087 cites W2034867106 @default.
• W2014164087 cites W2036393005 @default.
• W2014164087 cites W2041665747 @default.
• W2014164087 cites W2050865517 @default.
• W2014164087 cites W2061420085 @default.
• W2014164087 cites W2095793943 @default.
• W2014164087 cites W2137277510 @default.
• W2014164087 cites W2159689159 @default.
• W2014164087 cites W2160799497 @default.
• W2014164087 cites W2161332618 @default.
• W2014164087 cites W2164733112 @default.
• W2014164087 cites W2403571602 @default.
• W2014164087 cites W2527598162 @default.
• W2014164087 cites W2952084686 @default.
• W2014164087 cites W4211024586 @default.
• W2014164087 cites W60206895 @default.
• W2014164087 doi "https://doi.org/10.1002/ijc.1324" @default.
• W2014164087 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11410877" @default.
• W2014164087 hasPublicationYear "2001" @default.
• W2014164087 type Work @default.
• W2014164087 sameAs 2014164087 @default.
• W2014164087 citedByCount "96" @default.
• W2014164087 countsByYear W20141640872012 @default.
• W2014164087 countsByYear W20141640872013 @default.
• W2014164087 countsByYear W20141640872014 @default.
• W2014164087 countsByYear W20141640872015 @default.
• W2014164087 countsByYear W20141640872016 @default.
• W2014164087 countsByYear W20141640872017 @default.
• W2014164087 countsByYear W20141640872018 @default.
• W2014164087 countsByYear W20141640872019 @default.
• W2014164087 countsByYear W20141640872020 @default.
• W2014164087 countsByYear W20141640872021 @default.
• W2014164087 countsByYear W20141640872022 @default.
• W2014164087 countsByYear W20141640872023 @default.
• W2014164087 crossrefType "journal-article" @default.
• W2014164087 hasAuthorship W2014164087A5005835095 @default.
• W2014164087 hasAuthorship W2014164087A5008017292 @default.
• W2014164087 hasAuthorship W2014164087A5027622225 @default.
• W2014164087 hasAuthorship W2014164087A5035008429 @default.
• W2014164087 hasAuthorship W2014164087A5055843644 @default.
• W2014164087 hasAuthorship W2014164087A5067200658 @default.
• W2014164087 hasAuthorship W2014164087A5091862786 @default.
• W2014164087 hasBestOaLocation W20141640872 @default.
• W2014164087 hasConcept C110121322 @default.
• W2014164087 hasConcept C112705442 @default.
• W2014164087 hasConcept C121332964 @default.
• W2014164087 hasConcept C126322002 @default.
• W2014164087 hasConcept C134306372 @default.
• W2014164087 hasConcept C142724271 @default.
• W2014164087 hasConcept C178790620 @default.
• W2014164087 hasConcept C185592680 @default.
• W2014164087 hasConcept C202751555 @default.
• W2014164087 hasConcept C2777807558 @default.
• W2014164087 hasConcept C2777928079 @default.
• W2014164087 hasConcept C2778432610 @default.
• W2014164087 hasConcept C2781323092 @default.
• W2014164087 hasConcept C2781469039 @default.
• W2014164087 hasConcept C33923547 @default.
• W2014164087 hasConcept C502942594 @default.
• W2014164087 hasConcept C55493867 @default.
• W2014164087 hasConcept C62520636 @default.
• W2014164087 hasConcept C71924100 @default.
• W2014164087 hasConcept C75473681 @default.
• W2014164087 hasConcept C91881484 @default.
• W2014164087 hasConcept C98274493 @default.
• W2014164087 hasConceptScore W2014164087C110121322 @default.
• W2014164087 hasConceptScore W2014164087C112705442 @default.
• W2014164087 hasConceptScore W2014164087C121332964 @default.
• W2014164087 hasConceptScore W2014164087C126322002 @default.
• W2014164087 hasConceptScore W2014164087C134306372 @default.

• next