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- W2014164467 abstract "Prevailing evolutionary forces are typically deduced from the pattern of differences in synonymous and non-synonymous mutations, under the assumption of neutrality in the absence of amino acid change. We determined the complete sequence of ten vesicular stomatitis virus populations evolving under positive selection. A significant number of the mutations occurred independently in two or more strains, a process known as parallel evolution, and a substantial fraction of the parallel mutations were silent. Parallel evolution was also identified in non-coding regions. These results indicate that silent mutations can significantly contribute to adaptation in RNA viruses, and relative frequencies of synonymous and non-synonymous substitutions may not be useful to resolve their evolutionary history." @default.
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- W2014164467 date "2004-10-01" @default.
- W2014164467 modified "2023-09-24" @default.
- W2014164467 title "Positive Selection of Synonymous Mutations in Vesicular Stomatitis Virus" @default.
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- W2014164467 doi "https://doi.org/10.1016/j.jmb.2004.08.003" @default.
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