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• W2014164485 abstract "Intraventricular administration of the opioid peptide leucine-enkephalin has been reported to induce petit-mal-like seizures in rats. These seizures have been found to be an age-dependent phenomenon. In rats, the full manifestation of these seizures develops after 4 weeks of age during which time ethosuximide was effective in aborting these seizures, while phenytoin and phenobarbital were ineffective. The period associated with the development of enkephalin-induced seizures in rats coincides with an important milestone in pineal chronobiology. In rats, melatonin plasma levels peak at 3 weeks of age, a period which also corresponds with the emergence of melatonin circadian rhythms. It is proposed that melatonin mediates the anticonvulsant action of drugs effective for petit-mal (absence) epilepsy and that the pineal gland is implicated in the pathogenesis of this form of childhood epilepsy." @default.
• W2014164485 created "2016-06-24" @default.
• W2014164485 creator A5032905339 @default.
• W2014164485 date "1992-01-01" @default.
• W2014164485 modified "2023-09-27" @default.
• W2014164485 title "Melatonin and Petit-Mal Epilepsy: An Hypothesis" @default.
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• W2014164485 doi "https://doi.org/10.3109/00207459209003280" @default.
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