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- W2014165616 abstract "Gastrointestinal mixed adenoneuroendocrine carcinomas (MANECs) are rare tumors and, as the name implies, are characterized by the presence of both components, exocrine and neuroendocrine, each one representing at least 30% of the lesion.1 It is unclear if they originate from proliferation of different cell lineages or from stem cells capable of differentiating along multiple cell lineages. They may present as polypoid lesions, with variable size. Treatment and prognosis is determined by the more aggressive component.2 An 84-year-old woman was referred to upper gastrointestinal endoscopy for evaluation of dyspepsia. Endoscopic examination showed a 15 mm polypoid lesion with central ulceration in the anterior wall of gastric body and papulous gastropathy (Fig. 1). Biopsies of the gastric lesion showed a neuroendocrine tumor and random biopsies of the gastric mucosa showed chronic atrophic gastritis and intestinal metaplasia. Serum antibodies to parietal cells and to intrinsic factor were negative. Serum level of chromogranin A level was 129.6 ng/mL (normal level < 80 ng/mL). Thoracic and abdominal CT revealed neither locoregional adenopathies nor distant metastasis. Single-photon emission computed tomography showed no lesion with uptake" @default.
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- W2014165616 date "2015-01-01" @default.
- W2014165616 modified "2023-09-28" @default.
- W2014165616 title "Gastric Mixed Adenoneuroendocrine Carcinoma" @default.
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- W2014165616 doi "https://doi.org/10.1016/j.jpge.2014.07.003" @default.
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