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• W2014171130 abstract "Cholesterol- and sphingolipid-rich membrane microdomains termed lipid rafts appear to play a central role in B cell activation. In mature B cells, signaling through the B cell antigen receptor(BCR) is initiated from within rafts and leads to activation. In immature B cells, the BCR is excluded from rafts and signaling leads to apoptosis. CD40, a member of the tumor necrosis receptor family, is expressed by B cells throughout development and has been shown to influence the results of the engagement of antigen by the BCR in both mature B and immature B cells. Here evidence is provided that CD40 is excluded from the lipid rafts of both mature and immature B cells and remains excluded from rafts even after cross-linking. Nevertheless, in mature B cells CD40 signaling influences the association of the BCR with rafts resulting in an increase in the amount of BCR that translocates into rafts following ligand binding and a subsequent acceleration of the movement of the BCR from rafts. In immature B cells, the cross-linked BCR remains excluded from rafts in the presence of CD40 signaling, conditions under which BCR-induced apoptosis is blocked. These results indicate that CD40 functions outside lipid rafts to influence raft-dependent events in mature B cells and raft-independent events in immature B cells." @default.
• W2014171130 created "2016-06-24" @default.
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• W2014171130 creator A5025853358 @default.
• W2014171130 date "2001-12-01" @default.
• W2014171130 modified "2023-09-25" @default.
• W2014171130 title "The influence of CD40 on the association of the B cell antigen receptor with lipid rafts in mature and immature cells" @default.
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• W2014171130 doi "https://doi.org/10.1002/1521-4141(200112)31:12<3789::aid-immu3789>3.0.co;2-v" @default.
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