FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014171837> ?p ?o ?g. }

• W2014171837 abstract "We have previously shown that all six members of the anti-apoptotic BCL2 gene family can cooperate with (myelocytomatosis oncogene) MYC in a mouse model of leukemia, but three of them are significantly less potent contributors to leukemogenicity than the other three. The protein encoded by one of these less potent genes, BCL2L10/BCLb, was recently shown to vary dramatically in many primary human cancers by immunohistochemistry, and the protein levels were inversely correlated with survival in patients with several cancer types. We examined BCLb mRNA in a panel of human cancer cell lines and did not observe the extensive variation in mRNA that would be required to explain the vast differences in protein levels. We found that the levels of BCLb protein diminish quickly after inhibition of protein synthesis with cycloheximide, so we searched for interacting proteins that might affect posttranslational stability of BCLb. Using a variety of approaches, including immunoaffinity and mass spectrometry, we identified a protein, Ubiquilin1 (Ubqln), that specifically interacts with BCLb, and not with other anti-apoptotic BCL2-like proteins. Ubqln stabilizes BCLb protein, while also promoting monoubiquitination on multiple lysine residues and relocation to the cytosol. Furthermore, primary lung adencarcinomas have more Ubqln mRNA than normal adjacent lung tissue, and higher Ubqln mRNA levels are associated with shorter survival of lung cancer patients, suggesting that potentiation of the anti-apoptotic potential of BCLb through regulation of its stability by Ubqln may be an important factor in tumor progression." @default.
• W2014171837 created "2016-06-24" @default.
• W2014171837 creator A5023586836 @default.
• W2014171837 creator A5026356534 @default.
• W2014171837 creator A5035250507 @default.
• W2014171837 creator A5082796663 @default.
• W2014171837 creator A5088272548 @default.
• W2014171837 date "2012-01-10" @default.
• W2014171837 modified "2023-10-12" @default.
• W2014171837 title "Ubiquitination, localization, and stability of an anti-apoptotic BCL2-like protein, BCL2L10/BCLb, are regulated by Ubiquilin1" @default.
• W2014171837 cites W1497913243 @default.
• W2014171837 cites W1497941038 @default.
• W2014171837 cites W1964617786 @default.
• W2014171837 cites W1969429198 @default.
• W2014171837 cites W1977258127 @default.
• W2014171837 cites W1977290823 @default.
• W2014171837 cites W1986688227 @default.
• W2014171837 cites W1988170942 @default.
• W2014171837 cites W2015600776 @default.
• W2014171837 cites W2017028093 @default.
• W2014171837 cites W2017555329 @default.
• W2014171837 cites W2019583554 @default.
• W2014171837 cites W2019624477 @default.
• W2014171837 cites W2024812887 @default.
• W2014171837 cites W2027002330 @default.
• W2014171837 cites W2031217161 @default.
• W2014171837 cites W2034269086 @default.
• W2014171837 cites W2041064199 @default.
• W2014171837 cites W2046511938 @default.
• W2014171837 cites W2052920871 @default.
• W2014171837 cites W2056211184 @default.
• W2014171837 cites W2056418403 @default.
• W2014171837 cites W2058451329 @default.
• W2014171837 cites W2059826920 @default.
• W2014171837 cites W2060200458 @default.
• W2014171837 cites W2061050157 @default.
• W2014171837 cites W2065037500 @default.
• W2014171837 cites W2068962767 @default.
• W2014171837 cites W2072252062 @default.
• W2014171837 cites W2075317148 @default.
• W2014171837 cites W2085419794 @default.
• W2014171837 cites W2089298737 @default.
• W2014171837 cites W2107562621 @default.
• W2014171837 cites W2109421801 @default.
• W2014171837 cites W2115452399 @default.
• W2014171837 cites W2115885986 @default.
• W2014171837 cites W2121277695 @default.
• W2014171837 cites W2125192217 @default.
• W2014171837 cites W2144022982 @default.
• W2014171837 cites W2168046627 @default.
• W2014171837 cites W2171626531 @default.
• W2014171837 cites W4294107304 @default.
• W2014171837 doi "https://doi.org/10.1073/pnas.1119167109" @default.
• W2014171837 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3271887" @default.
• W2014171837 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22233804" @default.
• W2014171837 hasPublicationYear "2012" @default.
• W2014171837 type Work @default.
• W2014171837 sameAs 2014171837 @default.
• W2014171837 citedByCount "59" @default.
• W2014171837 countsByYear W20141718372012 @default.
• W2014171837 countsByYear W20141718372013 @default.
• W2014171837 countsByYear W20141718372014 @default.
• W2014171837 countsByYear W20141718372015 @default.
• W2014171837 countsByYear W20141718372016 @default.
• W2014171837 countsByYear W20141718372017 @default.
• W2014171837 countsByYear W20141718372018 @default.
• W2014171837 countsByYear W20141718372019 @default.
• W2014171837 countsByYear W20141718372020 @default.
• W2014171837 countsByYear W20141718372021 @default.
• W2014171837 countsByYear W20141718372022 @default.
• W2014171837 countsByYear W20141718372023 @default.
• W2014171837 crossrefType "journal-article" @default.
• W2014171837 hasAuthorship W2014171837A5023586836 @default.
• W2014171837 hasAuthorship W2014171837A5026356534 @default.
• W2014171837 hasAuthorship W2014171837A5035250507 @default.
• W2014171837 hasAuthorship W2014171837A5082796663 @default.
• W2014171837 hasAuthorship W2014171837A5088272548 @default.
• W2014171837 hasBestOaLocation W20141718371 @default.
• W2014171837 hasConcept C104317684 @default.
• W2014171837 hasConcept C105580179 @default.
• W2014171837 hasConcept C153911025 @default.
• W2014171837 hasConcept C190283241 @default.
• W2014171837 hasConcept C25602115 @default.
• W2014171837 hasConcept C2778128677 @default.
• W2014171837 hasConcept C2781018059 @default.
• W2014171837 hasConcept C29537977 @default.
• W2014171837 hasConcept C3675279 @default.
• W2014171837 hasConcept C502942594 @default.
• W2014171837 hasConcept C54355233 @default.
• W2014171837 hasConcept C86803240 @default.
• W2014171837 hasConcept C95444343 @default.
• W2014171837 hasConceptScore W2014171837C104317684 @default.
• W2014171837 hasConceptScore W2014171837C105580179 @default.
• W2014171837 hasConceptScore W2014171837C153911025 @default.
• W2014171837 hasConceptScore W2014171837C190283241 @default.
• W2014171837 hasConceptScore W2014171837C25602115 @default.
• W2014171837 hasConceptScore W2014171837C2778128677 @default.
• W2014171837 hasConceptScore W2014171837C2781018059 @default.
• W2014171837 hasConceptScore W2014171837C29537977 @default.
• W2014171837 hasConceptScore W2014171837C3675279 @default.

• next