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• W2014172391 abstract "Thiamine (vitamin B1) deficiency, associated with a variety of conditions, including chronic alcoholism and bariatric surgery for morbid obesity, can result in the neurological disorder Wernicke's encephalopathy (WE). Recent work building upon early observations in animal models of thiamine deficiency has demonstrated an inflammatory component to the neuropathology observed in thiamine deficiency. The present, multilevel study including in vivo magnetic resonance imaging (MRI) and spectroscopy (MRS) and postmortem quantification of chemokine and cytokine proteins sought to determine whether a combination of these in vivo neuroimaging tools could be used to characterize an in vivo MR signature for neuroinflammation. Thiamine deficiency for 12 days was used to model neuroinflammation; glucose loading in thiamine deficiency was used to accelerate neurodegeneration. Among 38 animals with regional brain tissue assayed postmortem for cytokine/chemokine protein levels, three groups of rats (controls + glucose, n = 6; pyrithiamine + saline, n = 5; pyrithiamine + glucose, n = 13) underwent MRI/MRS at baseline (time 1), after 12 days of treatment (time 2), and 3 h after challenge (glucose or saline, time 3). In the thalamus of glucose-challenged, thiamine deficient animals, correlations between in vivo measures of pathology (lower levels of N-acetyle aspartate and higher levels of lactate) and postmortem levels of monocyte chemotactic protein-1 (MCP-1, also known as chemokine ligand 2, CCL2) support a role for this chemokine in thiamine deficiency-related neurodegeneration, but do not provide a unique in vivo signature for neuroinflammation." @default.
• W2014172391 created "2016-06-24" @default.
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• W2014172391 date "2014-11-01" @default.
• W2014172391 modified "2023-10-15" @default.
• W2014172391 title "Associations between in vivo neuroimaging and postmortem brain cytokine markers in a rodent model of Wernicke's encephalopathy" @default.
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• W2014172391 doi "https://doi.org/10.1016/j.expneurol.2014.06.015" @default.
• W2014172391 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4194214" @default.
• W2014172391 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24973622" @default.
• W2014172391 hasPublicationYear "2014" @default.
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