FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014172552> ?p ?o ?g. }

• W2014172552 endingPage "456" @default.
• W2014172552 startingPage "449" @default.
• W2014172552 abstract "The carotenoid lycopene has been associated with decreased risks of several types of cancer, such as hepatoma. Although lycopene has been shown to inhibit metastasis, its mechanism of action is poorly understood. Here, we used SK-Hep-1 cells (from a human hepatoma) to test whether lycopene exerts its anti-invasion activity via down-regulation of the expression of matrix metalloproteinase (MMP)-9, an important enzyme in the degradation of basement membrane in cancer invasion. The activity and expressions of MMP-9 protein and mRNA were detected by gelatin zymography, Western blotting and RT-PCR, respectively. The binding abilities of nuclear factor-kappa B (NF-κB), activator protein-1 and stimulatory protein-1 (Sp1) to the binding sites in the MMP-9 promoter were measured by the electrophoretic mobility shift assay. We showed that lycopene (1–10 μM) significantly inhibited SK-Hep-1 invasion (P<.05) and that this effect correlated with the inhibition of MMP-9 at the levels of enzyme activity (r2=.94, P<.001), protein expression (r2=.80, P=.007) and mRNA expression (r2=.94, P<.001). Lycopene also significantly inhibited the binding abilities of NF-κB and Sp1 and decreased, to some extent, the expression of insulin-like growth factor-1 receptor (IGF-1R) and the intracellular level of reactive oxygen species (P<.05). The antioxidant effect of lycopene appeared to play a minor role in its inhibition of MMP-9 and invasion activity of SK-Hep-1 cells because coincubation of cells with lycopene plus hydrogen peroxide abolished the antioxidant effect but did not significantly affect the anti-invasion ability of lycopene. Thus, lycopene decreases the invasive ability of SK-Hep-1 cells by inhibiting MMP-9 expression and suppressing the binding activity of NF-κB and Sp1. These effects of lycopene may be related to the down-regulation of IGF-1R, while the antioxidant activity of lycopene appears to play a minor role." @default.
• W2014172552 created "2016-06-24" @default.
• W2014172552 creator A5019716618 @default.
• W2014172552 creator A5026174113 @default.
• W2014172552 creator A5078595510 @default.
• W2014172552 creator A5082620928 @default.
• W2014172552 date "2007-07-01" @default.
• W2014172552 modified "2023-10-14" @default.
• W2014172552 title "Lycopene inhibits matrix metalloproteinase-9 expression and down-regulates the binding activity of nuclear factor-kappa B and stimulatory protein-1" @default.
• W2014172552 cites W12952247 @default.
• W2014172552 cites W1551637284 @default.
• W2014172552 cites W1568529372 @default.
• W2014172552 cites W1786911182 @default.
• W2014172552 cites W1890561088 @default.
• W2014172552 cites W1905313439 @default.
• W2014172552 cites W1947132472 @default.
• W2014172552 cites W1969174237 @default.
• W2014172552 cites W1972495966 @default.
• W2014172552 cites W1980652294 @default.
• W2014172552 cites W1981682289 @default.
• W2014172552 cites W1985988868 @default.
• W2014172552 cites W1996353122 @default.
• W2014172552 cites W2000125965 @default.
• W2014172552 cites W2000591631 @default.
• W2014172552 cites W2011134969 @default.
• W2014172552 cites W2012197678 @default.
• W2014172552 cites W2013373958 @default.
• W2014172552 cites W2021159608 @default.
• W2014172552 cites W2025822929 @default.
• W2014172552 cites W2033624890 @default.
• W2014172552 cites W2040534704 @default.
• W2014172552 cites W2044736808 @default.
• W2014172552 cites W2057810394 @default.
• W2014172552 cites W2065135907 @default.
• W2014172552 cites W2071514866 @default.
• W2014172552 cites W2075703958 @default.
• W2014172552 cites W2076362571 @default.
• W2014172552 cites W2079975206 @default.
• W2014172552 cites W2080495834 @default.
• W2014172552 cites W2086246413 @default.
• W2014172552 cites W2086495242 @default.
• W2014172552 cites W2091536118 @default.
• W2014172552 cites W2093796745 @default.
• W2014172552 cites W2101591849 @default.
• W2014172552 cites W2104612138 @default.
• W2014172552 cites W2111678604 @default.
• W2014172552 cites W2116473125 @default.
• W2014172552 cites W2120003661 @default.
• W2014172552 cites W2125327817 @default.
• W2014172552 cites W2142054229 @default.
• W2014172552 cites W2158557623 @default.
• W2014172552 cites W2164157942 @default.
• W2014172552 cites W2171588423 @default.
• W2014172552 cites W2185110591 @default.
• W2014172552 cites W2329029967 @default.
• W2014172552 cites W2341253846 @default.
• W2014172552 cites W2397126425 @default.
• W2014172552 doi "https://doi.org/10.1016/j.jnutbio.2006.08.007" @default.
• W2014172552 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17049831" @default.
• W2014172552 hasPublicationYear "2007" @default.
• W2014172552 type Work @default.
• W2014172552 sameAs 2014172552 @default.
• W2014172552 citedByCount "106" @default.
• W2014172552 countsByYear W20141725522012 @default.
• W2014172552 countsByYear W20141725522013 @default.
• W2014172552 countsByYear W20141725522014 @default.
• W2014172552 countsByYear W20141725522015 @default.
• W2014172552 countsByYear W20141725522016 @default.
• W2014172552 countsByYear W20141725522017 @default.
• W2014172552 countsByYear W20141725522018 @default.
• W2014172552 countsByYear W20141725522019 @default.
• W2014172552 countsByYear W20141725522020 @default.
• W2014172552 countsByYear W20141725522021 @default.
• W2014172552 countsByYear W20141725522022 @default.
• W2014172552 countsByYear W20141725522023 @default.
• W2014172552 crossrefType "journal-article" @default.
• W2014172552 hasAuthorship W2014172552A5019716618 @default.
• W2014172552 hasAuthorship W2014172552A5026174113 @default.
• W2014172552 hasAuthorship W2014172552A5078595510 @default.
• W2014172552 hasAuthorship W2014172552A5082620928 @default.
• W2014172552 hasConcept C104317684 @default.
• W2014172552 hasConcept C109523444 @default.
• W2014172552 hasConcept C150194340 @default.
• W2014172552 hasConcept C153911025 @default.
• W2014172552 hasConcept C170493617 @default.
• W2014172552 hasConcept C183978625 @default.
• W2014172552 hasConcept C185592680 @default.
• W2014172552 hasConcept C2778004101 @default.
• W2014172552 hasConcept C2780022147 @default.
• W2014172552 hasConcept C48349386 @default.
• W2014172552 hasConcept C55493867 @default.
• W2014172552 hasConcept C86803240 @default.
• W2014172552 hasConcept C88045685 @default.
• W2014172552 hasConceptScore W2014172552C104317684 @default.
• W2014172552 hasConceptScore W2014172552C109523444 @default.
• W2014172552 hasConceptScore W2014172552C150194340 @default.
• W2014172552 hasConceptScore W2014172552C153911025 @default.
• W2014172552 hasConceptScore W2014172552C170493617 @default.

• next