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- W2014174191 abstract "Maternal immune activation (MIA) is a risk factor for autism and schizophrenia. However, how MIA affects offspring immune function remains unknown.To investigate the effect of MIA on the offspring, pregnant C57BL/6J mice were given an intraperitoneal injection of 50 μg/kg lipopolysaccharide (LPS) on gestational day 12.5.Adult LPS-treated offspring were hyper-reactive to LPS, and enhanced tumor necrosis factor-α production was observed. CD4+ T cells from LPS offspring had an elevated percentage of interferon (IFN)-γ(+) CD4+ T cells and interleukin (IL)-17A+ CD4+ T cells in the spleen, IL-17A+ CD4+ T cells in the liver, and CD4+ Foxp3+ T cells in the spleen. LPS offspring CD4+ T cells showed increased proliferation and an enhanced survival rate. DNA microarray analysis of resting LPS offspring CD4+ T cells identified eight up-regulated genes, most of which encoded transcription factors. Quantitative liquid chromatography-mass spectrometry identified 18 up-regulated proteins in resting LPS offspring CD4+ T cells and five up-regulated proteins in activated LPS offspring CD4+ T cells, most of which participated in the PANTHER Gene Ontology metabolic process.Our results showed that MIA to LPS up-regulated proteins involved in metabolic process in CD4+ T cells from LPS offspring that might contribute to the hyperactivated immune response of adult LPS offspring." @default.
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- W2014174191 date "2015-01-30" @default.
- W2014174191 modified "2023-10-16" @default.
- W2014174191 title "Maternal Lipopolysaccharide Exposure Promotes Immunological Functional Changes in Adult Offspring CD4<sup>+</sup>T Cells" @default.
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- W2014174191 cites W2004465286 @default.
- W2014174191 cites W2004647500 @default.
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- W2014174191 cites W2005730365 @default.
- W2014174191 cites W2011678998 @default.
- W2014174191 cites W2015419107 @default.
- W2014174191 cites W2015445169 @default.
- W2014174191 cites W2016827757 @default.
- W2014174191 cites W2018020394 @default.
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- W2014174191 cites W2037665124 @default.
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- W2014174191 cites W2044315491 @default.
- W2014174191 cites W2050179923 @default.
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- W2014174191 doi "https://doi.org/10.1111/aji.12364" @default.
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