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- W2014181631 abstract "The functional roles of adenosine A 3 receptors in the rat kidney were assessed for the first time with respect to A 1 receptor-mediated responses. Utilizing a chronically instrumented conscious rat preparation, we tested renal excretory responses to acute administration of the A 3 receptor antagonists 3-ethyl - 5-benzyl-2-methyl-6-phenyl- 4-phenylethynyl-1,4-(+)-dihydropridine-3,5-dicarboxylate (MRS-1191) and 9-chloro-2-(2-furyl)-5-phenylacetylamino- [1,2,4]-triazolo[1,5-c]quinazoline (MRS-1220) with reference to the effects of the A 1 receptor antagonist 1,3-dipropyl-8-cyclopentylxanthine (DPCPX). The intravenous administration of DPCPX resulted in significant increases in fluid and sodium excretions without affecting glomerular filtration rate (GFR). This suggests that DPCPX-induced diuretic and natriuretic responses are related to decreased tubular reabsorption. However, neither MRS-1191 nor MRS-1220 alone affected fluid or sodium excretions, or GFR, indicating lack of an effect of either compound on renal function. On the other hand, the co-administration of MRS-1220 with DPCPX abolished both the diuretic and natriuretic responses to DPCPX, being suggestive of antagonism between these two compounds. MRS-1191, however, did not affect the DPCPX-induced fluid and sodium excretions. Neither the A 1 nor the A 3 receptor antagonists altered potassium excretion individually or in combination. The data suggest that while adenosine A 1 receptors are involved in the regulation of renal fluid and sodium transport, A 3 receptors do not appear to have a major role in regulation of renal excretory function under baseline physiological conditions. Key words: adenosine A 3 receptor, adenosine antagonist, diuresis, natriuresis, rat." @default.
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- W2014181631 title "Renal adenosine A3 receptors in the rat: assessment of functional role" @default.
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- W2014181631 doi "https://doi.org/10.1139/y00-007" @default.
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