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- W2014183732 abstract "Letters and Corrections15 February 1990Continued Zidovudine and Interferon-Alpha Therapy in Kaposi Sarcoma and the Acquired Immunodeficiency Syndrome (AIDS)Ronald de Wit, MD, Piet J.M. Bakker, MD, Kees H.N. Veenhof, PhD, Sven A. Danner, PhDRonald de Wit, MDSearch for more papers by this author, Piet J.M. Bakker, MDSearch for more papers by this author, Kees H.N. Veenhof, PhDSearch for more papers by this author, Sven A. Danner, PhDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-112-4-306 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor:Kovacs and colleagues (1) recently reported on combined treatment with interferon-alpha and zidovudine in patients with the acquired immunodeficiency syndrome (AIDS)-associated Kaposi sarcoma. In their discussion, the question was raised whether the interferon-alpha alone or the combination was responsible for the antitumor activity. As we have shown in our previous single-agent interferon-alpha study (2), all major responses that were induced by the initial daily interferon-alpha schedule further improved or became complete responses during the thrice weekly maintenance schedule. Because Kovacs and colleagues escalated interferon-alpha towards high-dose during the initial 2 weeks as well, they may have induced...References1. KovacsDeytonDavey JLR. Combined zidovudine and interferon-alpha therapy in patients with Kaposi sarcoma and the acquired immunodeficiency syndrome (AIDS). Ann Intern Med. 1989;111:280-7. LinkGoogle Scholar2. de WitSchattenkerkBoucherBakkerVeenhofDanner RJCPKS. Clinical and virological effects of high-dose recombinant interferon-alpha in disseminated AIDS-related Kaposi's sarcoma. Lancet. 1988;2:1214-7. CrossrefMedlineGoogle Scholar3. LarderDarbyRichman BGD. HIV with reduced sensitivity to zidovudine (AZT) isolated during prolonged therapy. Science. 1989;243:1731-4. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Academic Medical Center Amsterdam the Netherlands PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByTHE ROLE OF RADIATION THERAPY IN THE MANAGEMENT OF HIV-RELATED KAPOSI'S SARCOMATreatment of Kaposi’s Sarcoma with Interferon-α and Other Biological Response ModifiersThe Potential Role of Cytokines in the Treatment of Viral InfectionsAre There Still Indications for Single Agent High-Dose Interferon-Alpha against AIDS-Associated Kaposi's Sarcoma? 15 February 1990Volume 112, Issue 4Page: 306-307KeywordsAIDSKaposi sarcoma Issue Published: 15 February 1990 PDF DownloadLoading ..." @default.
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- W2014183732 title "Continued Zidovudine and Interferon-Alpha Therapy in Kaposi Sarcoma and the Acquired Immunodeficiency Syndrome (AIDS)" @default.
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