FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014183778> ?p ?o ?g. }

• W2014183778 endingPage "1026" @default.
• W2014183778 startingPage "1018" @default.
• W2014183778 abstract "Nitric oxide (NO) can regulate chondrocyte activities. This study was aimed to evaluate the molecular mechanisms of NO donor sodium nitroprusside (SNP)-induced insults to human chondrocytes. Exposure of human chondrocytes to SNP increased cellular NO levels but decreased cell viability in concentration- and time-dependent manners. SNP time dependently induced DNA fragmentation and cell apoptosis. Treatment with 2-phenyl-4,4,5,5-tetramethyl-imidazoline-1-oxyl 3-oxide, an NO scavenger, significantly lowered SNP-induced cell injuries. Administration of SNP interrupted F-actin and microtubule cytoskeletons and stimulated phosphorylation of mitogen-activated protein kinase kinase kinase-1 (MEKK1) and c-Jun N-terminal kinase (JNK). Similar to SNP, cytochalasin D, an inhibitor of F-actin formation, disturbed F-actin polymerization and increased MEKK1 and JNK activations. Overexpression of a dominant negative mutant of MEKK1 (dnMEK1) in human chondrocytes significantly ameliorated SNP-induced cell apoptosis. Exposure to SNP promoted Bax translocation from the cytoplasm to mitochondria, but application of dnMEKK1 lowered the translocation. SNP time dependently decreased the mitochondrial membrane potential, complex I NADH dehydrogenase activity, and cellular ATP levels, but increased the release of cytochrome c from mitochondria to the cytoplasm. Activities of caspase-9, -3, and -6 were sequentially increased by SNP administration. This study shows that SNP can induce apoptosis of human chondrocytes through sequential events, including cytoskeletal remodeling, activation of MEKK1/JNK, Bax translocation, mitochondrial dysfunction, cytochrome c release, caspase activation, and DNA fragmentation. © 2008 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 26:1018–1026, 2008" @default.
• W2014183778 created "2016-06-24" @default.
• W2014183778 creator A5017589151 @default.
• W2014183778 creator A5022150628 @default.
• W2014183778 creator A5038207357 @default.
• W2014183778 creator A5060660262 @default.
• W2014183778 creator A5076215944 @default.
• W2014183778 creator A5082791789 @default.
• W2014183778 date "2008-01-01" @default.
• W2014183778 modified "2023-10-13" @default.
• W2014183778 title "Apoptotic insults to human chondrocytes induced by sodium nitroprusside are involved in sequential events, including cytoskeletal remodeling, phosphorylation of mitogen-activated protein kinase kinase kinase-1/c-Jun N-terminal kinase, and Bax-Mitochondria-Mediated caspase activation" @default.
• W2014183778 cites W1518531052 @default.
• W2014183778 cites W1662237934 @default.
• W2014183778 cites W1964073342 @default.
• W2014183778 cites W1964176183 @default.
• W2014183778 cites W1972426221 @default.
• W2014183778 cites W1974213596 @default.
• W2014183778 cites W1975096632 @default.
• W2014183778 cites W1976987011 @default.
• W2014183778 cites W1977914031 @default.
• W2014183778 cites W1980060975 @default.
• W2014183778 cites W2005856601 @default.
• W2014183778 cites W2008258524 @default.
• W2014183778 cites W2008977447 @default.
• W2014183778 cites W2009824727 @default.
• W2014183778 cites W2014825732 @default.
• W2014183778 cites W2024046612 @default.
• W2014183778 cites W2031726991 @default.
• W2014183778 cites W2035238168 @default.
• W2014183778 cites W2038055601 @default.
• W2014183778 cites W2038496625 @default.
• W2014183778 cites W2041831078 @default.
• W2014183778 cites W2047186390 @default.
• W2014183778 cites W2047571097 @default.
• W2014183778 cites W2053108974 @default.
• W2014183778 cites W2056031812 @default.
• W2014183778 cites W2063795634 @default.
• W2014183778 cites W2067489969 @default.
• W2014183778 cites W2074678011 @default.
• W2014183778 cites W2077280771 @default.
• W2014183778 cites W2082293892 @default.
• W2014183778 cites W2083086713 @default.
• W2014183778 cites W2101043399 @default.
• W2014183778 cites W2105612358 @default.
• W2014183778 cites W2115632410 @default.
• W2014183778 cites W2120378379 @default.
• W2014183778 cites W2134823467 @default.
• W2014183778 cites W2156770263 @default.
• W2014183778 cites W2163893998 @default.
• W2014183778 cites W2164332161 @default.
• W2014183778 doi "https://doi.org/10.1002/jor.20578" @default.
• W2014183778 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18306405" @default.
• W2014183778 hasPublicationYear "2008" @default.
• W2014183778 type Work @default.
• W2014183778 sameAs 2014183778 @default.
• W2014183778 citedByCount "50" @default.
• W2014183778 countsByYear W20141837782012 @default.
• W2014183778 countsByYear W20141837782013 @default.
• W2014183778 countsByYear W20141837782014 @default.
• W2014183778 countsByYear W20141837782015 @default.
• W2014183778 countsByYear W20141837782016 @default.
• W2014183778 countsByYear W20141837782017 @default.
• W2014183778 countsByYear W20141837782018 @default.
• W2014183778 countsByYear W20141837782021 @default.
• W2014183778 countsByYear W20141837782022 @default.
• W2014183778 crossrefType "journal-article" @default.
• W2014183778 hasAuthorship W2014183778A5017589151 @default.
• W2014183778 hasAuthorship W2014183778A5022150628 @default.
• W2014183778 hasAuthorship W2014183778A5038207357 @default.
• W2014183778 hasAuthorship W2014183778A5060660262 @default.
• W2014183778 hasAuthorship W2014183778A5076215944 @default.
• W2014183778 hasAuthorship W2014183778A5082791789 @default.
• W2014183778 hasConcept C153911025 @default.
• W2014183778 hasConcept C184235292 @default.
• W2014183778 hasConcept C185592680 @default.
• W2014183778 hasConcept C86803240 @default.
• W2014183778 hasConcept C95444343 @default.
• W2014183778 hasConcept C97029542 @default.
• W2014183778 hasConceptScore W2014183778C153911025 @default.
• W2014183778 hasConceptScore W2014183778C184235292 @default.
• W2014183778 hasConceptScore W2014183778C185592680 @default.
• W2014183778 hasConceptScore W2014183778C86803240 @default.
• W2014183778 hasConceptScore W2014183778C95444343 @default.
• W2014183778 hasConceptScore W2014183778C97029542 @default.
• W2014183778 hasIssue "7" @default.
• W2014183778 hasLocation W20141837781 @default.
• W2014183778 hasLocation W20141837782 @default.
• W2014183778 hasOpenAccess W2014183778 @default.
• W2014183778 hasPrimaryLocation W20141837781 @default.
• W2014183778 hasRelatedWork W1641042124 @default.
• W2014183778 hasRelatedWork W1990804418 @default.
• W2014183778 hasRelatedWork W1993764875 @default.
• W2014183778 hasRelatedWork W2013243191 @default.
• W2014183778 hasRelatedWork W2051339581 @default.
• W2014183778 hasRelatedWork W2082860237 @default.
• W2014183778 hasRelatedWork W2117258802 @default.
• W2014183778 hasRelatedWork W2130076355 @default.
• W2014183778 hasRelatedWork W2151865869 @default.

• next