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• W2014184356 abstract "Variants of the class I ligase ribozyme, which catalyzes joining of the 3′ end of a template bound oligonucleotide to its own 5′ end, have been made to evolve in a continuous manner by a simple serial transfer procedure that can be carried out indefinitely. This process was expanded to allow the evolution of ribozymes that catalyze three successive nucleotidyl addition reactions, two template-directed mononucleotide additions followed by RNA ligation. During the development of this behavior, a population of ribozymes was maintained against an overall dilution of more than 10406. The resulting ribozymes were capable of catalyzing the three-step reaction pathway, with nucleotide addition occurring in either a 5′→3′ or a 3′→5′ direction. This purely chemical system provides a functional model of a multi-step reaction pathway that is undergoing Darwinian evolution." @default.
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• W2014184356 date "2002-05-01" @default.
• W2014184356 modified "2023-10-15" @default.
• W2014184356 title "Continuous In Vitro Evolution of a Ribozyme that Catalyzes Three Successive Nucleotidyl Addition Reactions" @default.
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• W2014184356 doi "https://doi.org/10.1016/s1074-5521(02)00136-9" @default.
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