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- W2014186901 abstract "Background: Two-dimensional echo is the current method for detection of LV dysfunction in Duchenne muscular dystrophy (DMD), yet complete 2-D imaging is sub-optimal in most DMD patients. Tissue Doppler velocities (TDV) are abnormal in a number of cardiac conditions when standard indices of LV function are normal. Hypothesis: Detection of left ventricular dysfunction in DMD is enhanced by TDV. Methods: We report TDV data in 31 DMD patients (median age 17.5 yrs, range 11-34) and 13 age-matched controls. Thirty patients were wheelchair dependent; 14 required ventilation support. Standard 2-D images were sought. LV fractional shortening (FS) was obtained from the parasternal long-axis view. LV ejection fraction (LVEF) was a visual estimate since image quality was inadequate for quantitation. TDV were recorded from the septal and lateral aspects of the mitral annulus from an apical 4-chamber view. Offline measurements were obtained from digital images and reported as the average of 3 beats. Myocardial performance index (MPI) was derived from the septal recording of TDV and calculated as: [(isovolumic contraction time+isovolumic relaxation time+diastolic filling time) - ejection time]/ejection time. Abnormal TDV were defined as outside the 95% normal confidence limits reported for 131 healthy children. Results: TDV data could be recorded in 26 patients and all 13 controls. DMD patients had significantly lower TDV, particularly in early diastole, and the MPI was higher.Comparison of DMD versus ControlsParameterSeptal S cm/sSeptal E cm/sLateral S cm/sLateral E cm/sFS (%)LVEF (%)MPIDMD6.7±1.4∗∗8.7±2.0∗7.5±2.0∗10.9±3.2∗23±10∗47±13∗0.56±0.22∗Controls8.3±1.412.8±2.611.1±2.417.3±4.437.3±361±40.31±07Number abnormal2/2621/2612/2215/2225/3112/3019/24∗ p<0.001, ∗∗ p<0.01" @default.
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- W2014186901 date "2004-08-01" @default.
- W2014186901 modified "2023-09-24" @default.
- W2014186901 title "Early detection of the cardiomyopathy of duchenne muscular dystrophy is enhanced by tissue doppler imaging and myocardial performance index" @default.
- W2014186901 doi "https://doi.org/10.1016/j.cardfail.2004.06.080" @default.
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