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- W2014189836 abstract "Numerical studies on the detection of tumors using photoacoustic imaging have shown that relying on optical energy absorption by blood hemoglobin as the contrast mechanism leads to poor image quality. This provides a strong incentive for seeking suitable manufactured photoacoustic contrast agents (PACAs). We present a theoretical comparison of three different photoacoustic contrast agents, all incorporating dye particles with suitable optical absorption characteristics. The three different designs are as follows: (1) stabilized droplet: a droplet of dye; (2) stabilized bubble: a bubble filled with gas and coated by dye as the shell; and (3) phase shift droplet: a droplet of volatile dye, all pulsating in a homogenous incompressible fluid. For each case, the governing equations describing the dynamics of a single PACA and the radiated pressure are derived. Each case is expressed in terms of four coupled sets of equations as the pressure radiated from the bubble, equation of motion, photoacoustic energy equation and equation of state, by virtue of simplifying assumptions. The derived equations are numerically solved by the Runge–Kutta method, using appropriate photoacoustic properties. The numerical results predict a much stronger radiated acoustic signal for the same optical source energy in the case of the stabilized bubble (case 2)." @default.
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- W2014189836 date "2011-04-01" @default.
- W2014189836 modified "2023-09-26" @default.
- W2014189836 title "Investigating new photoacoustic contrast agents." @default.
- W2014189836 doi "https://doi.org/10.1121/1.3588797" @default.
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