FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014189869> ?p ?o ?g. }

• W2014189869 endingPage "3664" @default.
• W2014189869 startingPage "3659" @default.
• W2014189869 abstract "Although the presence of an exogenous anion is a requirement for tight Fe 3+ binding by the bacterial ( Neisseria ) transferrin n Fbp, the identity of the exogenous anion is not specific in vitro. n Fbp was reconstituted as a stable iron containing protein by using a number of different exogenous anions [arsenate, citrate, nitrilotriacetate, pyrophosphate, and oxalate (symbolized by X)] in addition to phosphate, predominantly present in the recombinant form of the protein. Spectroscopic characterization of the Fe 3+ /anion interaction in the reconstituted protein was accomplished by UV-visible and EPR spectroscopies. The affinity of the protein for Fe 3+ is anion dependent, as evidenced by the effective Fe 3+ binding constants ( K ′ eff ) observed, which range from 1 × 10 17 M −1 to 4 × 10 18 M −1 at pH 6.5 and 20°C. The redox potentials for Fe 3+ n FbpX/Fe 2+ n FbpX reduction are also found to depend on the identity of the synergistic anion required for Fe 3+ sequestration. Facile exchange of exogenous anions (Fe 3+ n FbpX + X′ → Fe 3+ n FbpX′ + X) is established and provides a pathway for environmental modulation of the iron chelation and redox characteristics of n Fbp. The affinity of the iron loaded protein for exogenous anion binding at pH 6.5 was found to decrease in the order phosphate > arsenate ∼ pyrophosphate > nitrilotriacetate > citrate ∼ oxalate ≫ carbonate. Anion influence on the iron primary coordination sphere through iron binding and redox potential modulation may have in vivo application as a mechanism for periplasmic control of iron delivery to the cytosol." @default.
• W2014189869 created "2016-06-24" @default.
• W2014189869 creator A5000702539 @default.
• W2014189869 creator A5024564522 @default.
• W2014189869 creator A5027698659 @default.
• W2014189869 creator A5032922712 @default.
• W2014189869 creator A5076405771 @default.
• W2014189869 creator A5078265256 @default.
• W2014189869 creator A5089285511 @default.
• W2014189869 date "2003-03-19" @default.
• W2014189869 modified "2023-10-15" @default.
• W2014189869 title "The influence of the synergistic anion on iron chelation by ferric binding protein, a bacterial transferrin" @default.
• W2014189869 cites W140882671 @default.
• W2014189869 cites W1442483700 @default.
• W2014189869 cites W1484203152 @default.
• W2014189869 cites W1547678744 @default.
• W2014189869 cites W1551307287 @default.
• W2014189869 cites W1973003920 @default.
• W2014189869 cites W1979395342 @default.
• W2014189869 cites W2001263732 @default.
• W2014189869 cites W2004862837 @default.
• W2014189869 cites W2006226969 @default.
• W2014189869 cites W2006636818 @default.
• W2014189869 cites W2019296008 @default.
• W2014189869 cites W2025500877 @default.
• W2014189869 cites W2027836860 @default.
• W2014189869 cites W2029870344 @default.
• W2014189869 cites W2033908128 @default.
• W2014189869 cites W2036651466 @default.
• W2014189869 cites W2037434347 @default.
• W2014189869 cites W2041787141 @default.
• W2014189869 cites W2050645194 @default.
• W2014189869 cites W2065338683 @default.
• W2014189869 cites W2066032732 @default.
• W2014189869 cites W2070254932 @default.
• W2014189869 cites W2088987937 @default.
• W2014189869 cites W2092454138 @default.
• W2014189869 cites W2131184459 @default.
• W2014189869 cites W2156691801 @default.
• W2014189869 cites W2313089471 @default.
• W2014189869 cites W2330239706 @default.
• W2014189869 cites W2414618189 @default.
• W2014189869 cites W426804056 @default.
• W2014189869 cites W75045388 @default.
• W2014189869 doi "https://doi.org/10.1073/pnas.0536897100" @default.
• W2014189869 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/152978" @default.
• W2014189869 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12646708" @default.
• W2014189869 hasPublicationYear "2003" @default.
• W2014189869 type Work @default.
• W2014189869 sameAs 2014189869 @default.
• W2014189869 citedByCount "69" @default.
• W2014189869 countsByYear W20141898692012 @default.
• W2014189869 countsByYear W20141898692013 @default.
• W2014189869 countsByYear W20141898692014 @default.
• W2014189869 countsByYear W20141898692016 @default.
• W2014189869 countsByYear W20141898692017 @default.
• W2014189869 countsByYear W20141898692019 @default.
• W2014189869 countsByYear W20141898692020 @default.
• W2014189869 countsByYear W20141898692023 @default.
• W2014189869 crossrefType "journal-article" @default.
• W2014189869 hasAuthorship W2014189869A5000702539 @default.
• W2014189869 hasAuthorship W2014189869A5024564522 @default.
• W2014189869 hasAuthorship W2014189869A5027698659 @default.
• W2014189869 hasAuthorship W2014189869A5032922712 @default.
• W2014189869 hasAuthorship W2014189869A5076405771 @default.
• W2014189869 hasAuthorship W2014189869A5078265256 @default.
• W2014189869 hasAuthorship W2014189869A5089285511 @default.
• W2014189869 hasBestOaLocation W20141898692 @default.
• W2014189869 hasConcept C11111787 @default.
• W2014189869 hasConcept C115624301 @default.
• W2014189869 hasConcept C116569031 @default.
• W2014189869 hasConcept C13965031 @default.
• W2014189869 hasConcept C170493617 @default.
• W2014189869 hasConcept C17165728 @default.
• W2014189869 hasConcept C178790620 @default.
• W2014189869 hasConcept C179104552 @default.
• W2014189869 hasConcept C181199279 @default.
• W2014189869 hasConcept C185592680 @default.
• W2014189869 hasConcept C197404232 @default.
• W2014189869 hasConcept C22814914 @default.
• W2014189869 hasConcept C2776043855 @default.
• W2014189869 hasConcept C2776351790 @default.
• W2014189869 hasConcept C2777132085 @default.
• W2014189869 hasConcept C2777764464 @default.
• W2014189869 hasConcept C502230775 @default.
• W2014189869 hasConcept C55493867 @default.
• W2014189869 hasConcept C55904794 @default.
• W2014189869 hasConcept C8010536 @default.
• W2014189869 hasConceptScore W2014189869C11111787 @default.
• W2014189869 hasConceptScore W2014189869C115624301 @default.
• W2014189869 hasConceptScore W2014189869C116569031 @default.
• W2014189869 hasConceptScore W2014189869C13965031 @default.
• W2014189869 hasConceptScore W2014189869C170493617 @default.
• W2014189869 hasConceptScore W2014189869C17165728 @default.
• W2014189869 hasConceptScore W2014189869C178790620 @default.
• W2014189869 hasConceptScore W2014189869C179104552 @default.
• W2014189869 hasConceptScore W2014189869C181199279 @default.
• W2014189869 hasConceptScore W2014189869C185592680 @default.

• next